78342-50-4 Usage
Description
(R)-2-amino-4-pentynoic acid methyl ester, also known as L-homopropargylglycine methyl ester, is a chemical compound characterized by the molecular formula C7H9NO2. It is an amino acid derivative featuring a pentynoic acid side chain and a methyl ester functional group. (R)-2-amino-4-pentynoic acid methyl ester holds promise in the fields of medicinal chemistry and pharmaceutical research due to its enzyme-inhibiting properties, specifically targeting aminotransferases and decarboxylases. Additionally, it can be utilized in the synthesis of biologically active compounds and serves as a valuable building block for constructing more complex molecules. However, it is crucial to exercise caution when handling and using this compound to prevent potential harmful effects.
Uses
Used in Pharmaceutical Research:
(R)-2-amino-4-pentynoic acid methyl ester is used as an enzyme inhibitor for targeting aminotransferases and decarboxylases, which are crucial in various metabolic pathways. Its ability to inhibit these enzymes makes it a valuable tool in the development of new drugs for treating specific diseases.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (R)-2-amino-4-pentynoic acid methyl ester is used as a building block for synthesizing biologically active compounds. Its unique structure and functional groups allow for the creation of novel molecules with potential therapeutic applications.
Used in Drug Synthesis:
(R)-2-amino-4-pentynoic acid methyl ester is used as a key intermediate in the synthesis of more complex drug molecules. Its incorporation into these molecules can enhance their pharmacological properties, such as potency, selectivity, and bioavailability.
Used in Chemical Synthesis:
Beyond its applications in the pharmaceutical and medicinal chemistry fields, (R)-2-amino-4-pentynoic acid methyl ester can also be utilized in various chemical synthesis processes. Its versatile structure and functional groups make it a valuable component in the creation of a wide range of chemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 78342-50-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,3,4 and 2 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 78342-50:
(7*7)+(6*8)+(5*3)+(4*4)+(3*2)+(2*5)+(1*0)=144
144 % 10 = 4
So 78342-50-4 is a valid CAS Registry Number.
78342-50-4Relevant articles and documents
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity
Ourailidou, Maria E.,Lenoci, Alessia,Zwergel, Clemens,Rotili, Dante,Mai, Antonello,Dekker, Frank J.
, p. 847 - 856 (2017/02/05)
The implications of lysine-specific demethylase-1 (LSD1) in tumorigenesis have urged scientists to develop diagnostic tools in order to explore the function of this enzyme. In this work, we present our efforts on the development of tranylcypromine (TCP)-based functionalized probes for activity-based protein profiling (ABPP) of LSD1 activity. Biotinylated forms of selected compounds enabled dose-dependent enzyme labeling of recombinant LSD1. However, treatment with LSD1 inhibitors did not clearly reduce the LSD1 labeling efficiency thus indicating that labeling using these probes is not activity dependent. This calls for alternative strategies to develop probes for ABPP of the enzyme LSD1.
NOVEL B1 BRADYKININ RECEPTOR ANTAGONISTS
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Page/Page column 49-50, (2010/11/08)
The invention encompasses novel compounds of a formula I and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for treatment of diseases mediated by B1 bradykinin receptor.
ENANTIOSELECTIVE SYNTHESIS OF NON-PROTEINOGENIC AMINO ACIDS VIA METALLATED BIS-LACTIM ETHERS OF 2,5-DIKETOPIPERAZINES
Schoellkopf, Ulrich
, p. 2085 - 2092 (2007/10/02)
Bis-lactim ethers 1 of 2,5-diketopiperazines contain a chiral inducing center, an acidic CH-bond and two sites susceptible to hydrolysis.They react with BuLi to give Li compounds of type 4, 15, 29 or 32, which possess a prochiral C atom.They readily add electrophiles (such as alkylating agents or carbonyl compounds) with unusually high diastereoface differentiation.In many cases the d.e-value (d.e. = diastereomeric excess = asymmetric induction) of the adduct exceeds 95percent.On hydrolysis the adducts are cleaved liberating the chiral auxiliary (used to build up the bis-lactim ether 1) and the target molecules, the optically active amino acid methyl esters of type 8, 19, 25 or 36.The two amino acid esters are separable either by fractional distillation or (eventually after further hydrolysis to amino acids) by chromatography.Transition state models are discussed that could explain the exceptionally high asymmetric induction and the predictability of the induced configuration.
