78358-91-5

Basic information

• Product Name: Carbamic acid, (3-bromopropyl)-, (4-nitrophenyl)methyl ester
• CAS NO: 78358-91-5
• Molecular Formula: C11H13BrN2O4
• Molecular Weight: 317.139
• Mol File: 78358-91-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (3-bromopropyl)-, (4-nitrophenyl)methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (3-bromopropyl)-, (4-nitrophenyl)methyl ester(78358-91-5)
• EPA Substance Registry System: Carbamic acid, (3-bromopropyl)-, (4-nitrophenyl)methyl ester(78358-91-5)

Safety Data

• Hazardous Substances Data: 78358-91-5(Hazardous Substances Data)

Upstream product

• 18370-81-5 (3-bromopropyl)amine 
• 4457-32-3 4-nitrobenzyl chloroformate 

Downstream Products

• 873584-05-5 4-[3-(4-nitrobenzyloxycarbonylamino)propyl]piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Design, synthesis and evaluation of graftable thrombin inhibitors for the preparation of blood-compatible polymer materials

Piperazinyl-amide derivatives of N-α-(3-trifluoromethyl- benzenesulfonyl)-L-arginine (1) were synthesized as graftable thrombin inhibitors. The possible disturbance of biological activity due to a variable spacer-arm fixed on the N-4 piperazinyl position was evaluated in vitro, against human a-thrombin, and in blood coagulation assay. Molecular modelling (in silico analysis) and X-ray diffraction studies of thrombin-inhibitor complexes were also performed. The fixation of bioactive molecules on poly(butylene terephthalate) (PBT) and poly(ethylene terephthalate) (PET) membranes was performed by wet chemistry treatment and evaluated by XPS analysis. Surface grafting of inhibitor Id improved the membrane hemocompatibility by reducing blood clot formation on the modified surface. The Royal Society of Chemistry 2005.