78386-74-0Relevant articles and documents
Potassium tert-Butoxide-Mediated Condensation Cascade Reaction: Transition Metal-Free Synthesis of Multisubstituted Aryl Indoles and Benzofurans
Yang, Pengfei,Xu, Weiyan,Wang, Rongchao,Zhang, Min,Xie, Chunsong,Zeng, Xiaofei,Wang, Min
, p. 3658 - 3662 (2019/05/17)
An efficient and facile method to synthesize valuable disubstituted 2-aryl indoles and benzofurans in good yields has been demonstrated, based on a tert-butoxide-mediated condensation reaction involving a vinyl sulfoxide intermediate. Products are obtained from N- or O-benzyl benzaldehydes using dimethyl sulfoxide as a carbon source. The methodology features a wide functional group tolerance and transition metal-free environment. Preliminary mechanistic studies suggest that the reaction involves a tandem aldol reaction/Michael addition/dehydrosulfenylation/isomerization sequence through an ionic protocol.
A Versatile, Traceless C-H Activation-Based Approach for the Synthesis of Heterocycles
Zhou, Shuguang,Wang, Jinhu,Zhang, Feifei,Song, Chao,Zhu, Jin
, p. 2427 - 2430 (2016/06/09)
A versatile, traceless C-H activation-based approach for the synthesis of diversified heterocycles is reported. Rh(III)-catalyzed, N-amino-directed C-H alkenylation generates either olefination products or indoles (in situ annulation) in an atom- and step-economic manner at room temperature. The remarkable reactivity endowed by this directing group enables scale-up of the reaction to a 10 g scale at a very low catalyst loading (0.01 mol %/0.1 mol %). Ex situ annulation of olefination product provides entry into an array of heterocycles.
UNE NOUVELLE METHOXYLATION D'HYDROPEROXY-3 INDOLINES ISSUES DE LA PHOTO-OXYGENATION D'INDOLES EN MILIEU REDUCTEUR
Amsterdamsky, Claude,Rigaudy, Jean
, p. 1403 - 1406 (2007/10/02)
3-Hydroperoxy-1,3,6-trimethyl-2-phenyl indolines coming from the senzitized photo-oxygenation of the indoles in presence of KBH4 rearrange partially in basic methanol into the corresponding 3-hydroxy-6-methoxymethylindolines.
