784-98-5Relevant articles and documents
A new and efficient method for the synthesis of 3-(2-nitrophenyl)pyruvic acid derivatives and indoles based on the Reissert reaction
Mamedov, Vakhid A.,Mamedova, Vera L.,Syakaev, Victor V.,Khikmatova, Gul'naz Z.,Korshin, Dmitry E.,Kushatov, Temur A.,Latypov, Shamil K.
, p. 3923 - 3925 (2018/10/02)
The formation of 3-(2-nitrophenyl)pyruvic acid and its amide and ester derivatives – key compounds for the Reissert indole synthesis – was achieved under various reaction conditions via the acid catalyzed hydrolysis of 5-(2-nitrobenzyliden)-2,2-dimethyl-1,3-oxazolidin-4-one, which is readily available from 3-(2-nitrophenyl)oxirane-2-carboxamide. A new and highly efficient method for the synthesis of indole-2-carboxylic acid derivatives via the intramolecular reductive cyclization of o-nitrophenylpyruvic acid and its amide and ester derivatives was developed using Na2S2O4 in dioxane/water at reflux.
A Pd/C reduction method adopting water as a solvent for preparing indole-2-carboxylic acid
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Paragraph 0009; 0011; 0013; 0015, (2017/04/26)
The invention relates to a Pd/C reduction method adopting water as a solvent for preparing indole-2-carboxylic acid. Ethyl 2-nitrophenyl pyruvate is subjected to hydrogenation reduction cyclization in a high-pressure reaction kettle by adopting water as the solvent and adopting Pd/C as a catalyst, the Pd/C is recovered by filtering, and a filtrate is subjected to distillation, acidity adjustment and crystallization to obtain the indole-2-carboxylic acid. The catalyst is easily available and low in cost and can be repeatedly used. According to the method, the raw material can be easily recovered, post-treatment operation is simple, environment pollution is low, reaction operation safety is high, a reaction yield is high, and product quality is good, thus facilitating industrialization.
Methylglucoside phenylpyruvic acid Antidiabetes enolic type (by machine translation)
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Paragraph 0071, (2016/10/31)
PROBLEM TO BE SOLVED: pharmaceutical, especially sugar normal agent, in other words, for antiobestic, before the diabetes, or diabetes, Antiobesic and/or of a mammal having X syndrome sugar is lowered to a normal value to be used as a medicine, phenylpyruvic acid and its derivatives methylglucoside antidiabetes enolic type. SOLUTION: the compound of the present invention, useful for managing hypoglycaemia, in other words, by balancing hypoglycaemia physical condition; a balanced sugar, especially of human diabete balanced helps keep the blood sugar level; by sthenia gulucose taken by cells, by lowering the value of sugar helps and, hence, to improve the recovery or tolerance; optimizing a sugar response; tolerance. Selected drawing: no (by machine translation)