78473-70-8

Basic information

• Product Name: trans-Dihydro-3,4-bis[(3-Methoxyphenyl)Methyl]-2(3H)-furanone
• Synonyms: (3R,4R)-rel-Dihydro-3,4-bis[(3-Methoxyphenyl)Methyl]-2(3H)-furanone;3,4-BisMethoxy rac Enterolactone;trans-Dihydro-3,4-bis[(3-Methoxyphenyl)Methyl]-2(3H)-furanone
• CAS NO: 78473-70-8
• Molecular Formula: C₂₀H₂₂O₄
• Molecular Weight: 326.38628
• Product Categories: Apoptosis;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 78473-70-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• CAS DataBase Reference: trans-Dihydro-3,4-bis[(3-Methoxyphenyl)Methyl]-2(3H)-furanone(CAS DataBase Reference)
• NIST Chemistry Reference: trans-Dihydro-3,4-bis[(3-Methoxyphenyl)Methyl]-2(3H)-furanone(78473-70-8)
• EPA Substance Registry System: trans-Dihydro-3,4-bis[(3-Methoxyphenyl)Methyl]-2(3H)-furanone(78473-70-8)

Safety Data

• Hazardous Substances Data: 78473-70-8(Hazardous Substances Data)

Usage

Uses

rac Enterolactone (E558950) derivative.

Upstream product

• 77756-17-3 trans-2,3-bis(3-methoxybenzyl)-4-butanolide 
• 81436-88-6 bis(3-methoxybenzylidene)succinic acid 
• 591-31-1 3-methoxy-benzaldehyde 
• 61227-48-3 [(3-methoxyphenyl)methyl]propanedioic acid diethyl ester 
• 77756-13-9 2-<(3-methoxyphenyl)methyl>-1,3-propanediol 
• 77756-15-1 3-Hydroxymethyl-4-(3-methoxy-phenyl)-butyronitrile 
• 77756-14-0 Toluene-4-sulfonic acid 2-hydroxymethyl-3-(3-methoxy-phenyl)-propyl ester 
• 86653-16-9 4-<(3-methoxyphenyl)methyl>dihydrofuran-2(3H)-one 
• 104079-35-8 (2R,3R)-3-Hydroxymethyl-2-(3-methoxy-benzyl)-4-(3-methoxy-phenyl)-butyric acid methyl ester 
• 78473-69-5 3-(3-methoxybenzyl)-4-<3-methoxy-α,α-bis(phenylthio)benzyl>butyrolactone 
• 874-98-6 1-bromomethyl-3-methoxybenzene 
• 86653-15-8 4-(3-methoxybenzyl)-2(5H)-furanone 
• 10516-71-9 3-(3-Methoxy-phenyl)-propionic acid 
• 6099-04-3 3-methoxycinnamic acid 

Downstream Products

• 76543-15-2 (3S,4R)-3,4-Bis-(3-hydroxy-benzyl)-dihydro-furan-2-one 
• 76543-15-2 trans-2,3-bis[(3-hydroxyphenyl)methyl]-γ-butyrolactone 
• 77756-17-3 2,3-bis(3-methoxybenzyl)-4-butanolide 
• 138306-21-5 trans-3,4-bis(3-methoxybenzyl)tetrahydrofuran 
• 76543-15-2 (-)-enterolactone 
• 77756-23-1 Meso-2,3-bis-[(3-hydroxyphenyl)methyl]-1,4-butane diol 
• 76543-16-3 2,3-bis(3-hydroxybenzyl)-butane-1,4-diol 

Relevant articles and documents

A short synthesis of biologically active lignan analogues

β-Benzyl-γ-butyrolactones were synthesized in four transition metal catalysed reactions from butynediol, and alkylated to afford new, biologically active lignan analogues.

Tri-n-butyltin Hydride assisted Highly Stereoselective Lactonisation of Homoallylic Xanthates

A highly stereo- and regio-selective radical cyclisation of homoallylic xanthate esters is presented and the reaction is applied to the synthesis of some ring fused lactones.

OXIDATIVE COUPLING. II. THE TOTAL SYNTHESIS OF ENTEROLACTONE

Oxidative coupling of 3-methoxyhydrocinnamic acid dianion with molecular iodine forms the key step in an efficient synthesis of enterolactone.