78501-60-7

Basic information

• Product Name: Pentanoic acid, 5-(acetyloxy)-3-hydroxy-3-methyl-
• CAS NO: 78501-60-7
• Molecular Formula: C8H14O5
• Molecular Weight: 190.196
• Mol File: 78501-60-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pentanoic acid, 5-(acetyloxy)-3-hydroxy-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 5-(acetyloxy)-3-hydroxy-3-methyl-(78501-60-7)
• EPA Substance Registry System: Pentanoic acid, 5-(acetyloxy)-3-hydroxy-3-methyl-(78501-60-7)

Safety Data

• Hazardous Substances Data: 78501-60-7(Hazardous Substances Data)

Upstream product

• 87894-65-3 3-acetoxy-3-methylpentane-1,5-dioic acid anhydride 

Relevant articles and documents

Reinvestigation of a Synthesis of (R,S)-Mevalonolactone

An n.m.r. study of the reaction of 3-hydroxy-3-methylpentane-1,5-dioic acid (5) with excess of acetic anhydride is described.It has shown that 3-hydroxy-3-methylpentane-1,5-dioic acid anhydride (2), previously described by Scott and Shishido as an intermediate in their synthesis of mevalonolactone, is formed only transiently, along with 3-acetoxy-3-methylpentane-1,5-dioic acid (6).Both intermediates eventually give 3-acetoxy-3-methylpentane-1,5-dioic acid anhydride (3).To obtain (R,S)-mevalonolactone, sodium borohydride reduction of 3-hydroxy-3-methylpentane-1,5-dioic acid anhydride (2), prepared from the diacid (5) and N,N-dicyclohexylcarbodi-imide, is shown to be better than reduction of 3-acetoxy-3-methylpentane-1,5-dioic acid anhydride (3).