78502-73-5Relevant articles and documents
N-Bromosuccinimide Bromination of Substituted Methylthiazoles
Krieg, Benno,Mittner, Juergen
, p. 623 - 632 (2007/10/02)
Bromination of methylthiazoles with one unsubstituted position by N-bromosuccinimide may take place either at the methyl group, at the heterocyclic nucleus, or at both positions according to the nature of the second substituent.The ethoxycarbonyl group in the compounds 1a-3a directs the bromine into the side chain.So it is possible to obtain the tribromomethyl compounds 1d and 2d without bromination of the thiazole nucleus.In the phenyl-substituted methylthiazoles 4a-6a bromination takes place in the methyl group and in the heterocyclic nucleus. - The bromomethylthiazoles 1b-3b yield the vinylthiazoles 1k-3k by Wittig reaction.