785032-26-0

Basic information

• Product Name: 3-BroMo-N-Methyl-benzeneethanaMine
• Synonyms: 3-BroMo-N-Methyl-benzeneethanaMine;N-[2-(3-Bromophenyl)ethyl]-N-methylamine
• CAS NO: 785032-26-0
• Molecular Formula: C₉H₁₂BrN
• Molecular Weight: 214.10228
• Mol File: 785032-26-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-BroMo-N-Methyl-benzeneethanaMine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BroMo-N-Methyl-benzeneethanaMine(785032-26-0)
• EPA Substance Registry System: 3-BroMo-N-Methyl-benzeneethanaMine(785032-26-0)

Safety Data

• Hazardous Substances Data: 785032-26-0(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 58971-11-2 2-(3-bromophenyl)ethanamine 
• 40422-70-6 1-bromo-3-(2-bromoethyl)benzene 
• 74-89-5 methylamine 
• 64-18-6 formic acid 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 774214-05-0 2-(3-bromophenyl)-N,N-dimethylethanamine 

Relevant articles and documents

Design and synthesis of novel meta-linked phenylglycine macrocyclic FVIIa inhibitors

Two novel series of meta-linked phenylglycine-based macrocyclic FVIIa inhibitors have been designed to improve the rodent metabolic stability and PK observed with the precursor para-linked phenylglycine macrocycles. Through iterative structure-based design and optimization, the TF/ FVIIa Ki was improved to subnanomolar levels with good clotting activity, metabolic stability, and permeability.

Synthesis and evaluation of [11C]Cimbi-806 as a potential PET ligand for 5-HT7 receptor imaging

2-(2′,6′-Dimethoxy-[1,1′-biphenyl]-3-yl)-N, N-dimethylethanamine has been identified as a potent ligand for the serotonin 7 (5-HT7) receptor. In this study, we describe the synthesis, radiolabeling and in vivo evaluation of [11C]2-(2

Structure-activity correlations for β-phenethylamines at human trace amine receptor 1

A cell line in which RD-HGA16 cells were stably transfected with the hTAAR 1 receptor was created and utilized to carry out a systematic evaluation of a series of β-phenethylamines. Fair agreement was observed with data obtained for aryl and ethylene chain substituted analogs in an AV12-664 cell line in which hemagglutinin-tagged hTAAR 1 was stably co-expressed with rat Gαs. Analogs with multiple substituents as well as analogs with bulky groups were found to be partial agonists. Analogs in which the primary amino group was converted to a secondary or a tertiary amino group by N-methylation were also partial agonists. Comparative Molecular Field Analysis (CoMFA) using the potency data yielded a regression coefficient r2 of 0.824. The steric field contribution to the model was 61% with the balance (39%) contributed by the electrostatic field. The collective results suggest that increasing steric bulk both at the amino nitrogen, particularly by N-dimethylation, and at the 4-position of the aromatic ring leads to low efficacy ligands.