78526-50-8

Basic information

• Product Name: Pyridine, 4-[(4-methylphenyl)thio]-
• CAS NO: 78526-50-8
• Molecular Formula: C12H11NS
• Molecular Weight: 201.292
• Mol File: 78526-50-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Pyridine, 4-[(4-methylphenyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 4-[(4-methylphenyl)thio]-(78526-50-8)
• EPA Substance Registry System: Pyridine, 4-[(4-methylphenyl)thio]-(78526-50-8)

Safety Data

• Hazardous Substances Data: 78526-50-8(Hazardous Substances Data)

Upstream product

• 78526-32-6 2,6-Dimethyl-4'-p-tolylsulfanyl-4'H-[1,1']bipyridinyl-4-one 
• 15854-87-2 4-iodopyridine 
• 624-31-7 4-tolyl iodide 
• 106-45-6 para-thiocresol 
• 626-61-9 4-Chloropyridine 
• 504-24-5 4-aminopyridine 
• 38078-55-6 sodium S-(4-methylphenyl) thiosulfate 
• 1692-15-5 4-pyridylboronic acid 

Relevant articles and documents

Coupling of thiols and aromatic halides promoted by diboron derived super electron donors

We have proven that pyridine-boryl complexes can be used as superelectron donors to promote the coupling of thiols and aromatic halides through a SRN1 mechanism. The reaction is efficient for a broad substrate scope, tolerating heterocycles including pyridines, enolizable or reducible functional groups. The method has been applied to intermediates in drug synthesis as well as interesting functionalized polythioethers through a controlled and consecutive intramolecular electron transfer process.

An aryl thioether synthetic method of the compound

The invention discloses a synthetic method of an aryl sulfide type compound shown by a formula (3). In a reaction solvent, an aryl or alkenyl thiosulfate type derivative and a boric acid, boric acid grease or borate type derivative are used as reaction raw materials and react with each other to obtain a polysubstituted aryl sulfide type compound under the action of a metal copper catalyst. According to the synthetic method disclosed by the invention, reaction conditions are mild, raw materials are easily-available and low in price, the reaction operation is simple, the yield is relatively high, and a key skeleton structure is provided for the synthesis of many natural products and medicaments, so that the method can be widely applicable to industrial scale production. A formula is shown in the specification.

CO2-promoted oxidative cross-coupling reaction for C-S bond formation via masked strategy in an odourless way

Cu-catalyzed direct oxidative cross-coupling between boronic acids and masked sulfides delivering thioethers was described, in which the SO3-, as a mask, has shown a distinctive effect on the oxidative cross-coupling condition. Disulfide could be suppressed efficiently via masked strategy under CO2 atmosphere. A broad scope of aromatics and scalable processes indicates its practicality, which could be further applied to drug late-stage modification and unsymmetrical dibenzothiophenes (DBTs) synthesis.