78531-29-0

Basic information

• Product Name: 2-Amino-1,3-dimethoxypropane
• Synonyms: 1,3-dimethoxy-2-aminopropane;1,3-Dimethoxypropan-2-amine;2-AMINO-1,3-DIMETHOXYPROPANE;2-Amino-1,3-dimethoxy propan
• CAS NO: 78531-29-0
• Molecular Formula: C₅H₁₃NO₂
• Molecular Weight: 119.16
• Product Categories: pharmacetical
• Mol File: 78531-29-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 160.8°C at 760 mmHg
• Flash Point: 52°C
• Appearance: /
• Density: 0.932g/cm³
• Vapor Pressure: 2.35mmHg at 25°C
• Refractive Index: 1.417
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.00±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-1,3-dimethoxypropane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-1,3-dimethoxypropane(78531-29-0)
• EPA Substance Registry System: 2-Amino-1,3-dimethoxypropane(78531-29-0)

Safety Data

• RIDADR: 2735
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 78531-29-0(Hazardous Substances Data)

Usage

General Description

2-Amino-1,3-dimethoxypropane, also known as DMAP, is a chemical compound with the molecular formula C5H13NO2. It is a clear, colorless liquid with a faint odor and is commonly used as a reagent in organic synthesis. DMAP is known for its nucleophilic properties and is often used as a catalyst in various chemical reactions, particularly in the formation of amide and ester bonds. It also serves as a precursor for the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. However, DMAP can be hazardous if not handled properly, as it is flammable and can cause irritation to the skin, eyes, and respiratory system. Therefore, it is important to use proper safety precautions when working with this chemical. Overall, DMAP plays a crucial role in the field of organic chemistry and has various applications in the production of important chemical compounds.

InChI:InChI=1/C5H13NO2/c1-7-3-5(6)4-8-2/h5H,3-4,6H2,1-2H3

Upstream product

• 453548-89-5 1,3-dimethoxy-2-azidopropane 

Relevant articles and documents

Mechanism of Helix Induction on a Stereoregular Poly((4-carboxyphenyl)acetylene) with Chiral Amines and Memory of the Macromolecular Helicity Assisted by Interaction with Achiral Amines

Cis-transoidal poly((4-carboxyphenyl)acetylene) (poly-1) is an optically inactive polymer but forms an induced one-handed helical structure upon complexation with optically active amines such as (R)-(1-(1-naphthyl)ethyl) amine ((R)-2) in DMSO. The complexes show a characteristic induced circular dichroism (ICD) in the UV-visible region of the polymer backbone. Moreover, the macromolecular helicity of poly-1 induced by (R)-2 can be "memorized" even after complete replacement of (R)-2 by various achiral amines. We now report fully detailed studies on the mechanism of the helicity induction and memory of the helical chirality of poly-1 by means of UV-visible, CD, and infrared spectroscopies. We have found that a one-handed helix is cooperatively induced on poly-1 upon the ion pair formation of the carboxy groups of poly-1 with optically active amines and that the bulkiness of the chiral amines plays a crucial role for inducing an excess of a single-handed helix. On the other hand, the free ion formation was found to be essential for the macromolecular helicity memory of poly-1 after the replacement of the chiral amine by achiral amines, since the intramolecular electrostatic repulsion between the neighboring carboxylate ions of poly-1 significantly contributes to reduce the atropisomerization process of poly-1. On the basis of the mechanism of helicity induction and the memory of the helical chirality drawn from the present studies, we succeeded in creating an almost perfect memory of the induced macromolecular helicity of poly-1 with (R)-2 by using 2-aminoethanol as an achiral chaperoning molecule to assist in maintaining the memory of helical chirality.