78554-68-4

Basic information

• Product Name: 4-AMinobenzo-12-crown-4
• Synonyms: 4-AMinobenzo-12-crown-4
• CAS NO: 78554-68-4
• Molecular Formula: C₁₂H₁₇NO₄
• Molecular Weight: 240.27562
• Mol File: 78554-68-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-AMinobenzo-12-crown-4(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMinobenzo-12-crown-4(78554-68-4)
• EPA Substance Registry System: 4-AMinobenzo-12-crown-4(78554-68-4)

Safety Data

• Hazardous Substances Data: 78554-68-4(Hazardous Substances Data)

Upstream product

• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 

Downstream Products

• 474335-60-9 N-(13-(2-phenylethynyl)-2,3,5,6,8,9-hexahydro-1,4,7,10-tetraoxabenzocyclododecen-12-yl)acetamide 
• 474335-61-0 N-{13-[2-(4-methoxyphenyl)ethynyl]-2,3,5,6,8,9-hexahydro-1,4,7,10-tetraoxabenzocyclododecen-12-yl}acetamide 
• 474335-62-1 N-{13-[2-(4-nitrophenyl)ethynyl]-2,3,5,6,8,9-hexahydro-1,4,7,10-tetraoxabenzocyclododecen-12-yl}acetamide 
• 172693-84-4 1⁴-<4-phenyldiazenyl>-2,5,8,11-tetraoxa-1(1,2)-benzenacycloundecaphane 
• 172693-85-5 1⁴-<4-phenyldiazenyl>-2,5,8,11-tetraoxa-1(1,2)-benzenacycloundecaphane 
• 172693-82-2 1⁴-<4-phenyldiazenyl>-2,5,8,11-tetraoxa-1(1,2)-benzenacycloundecaphane 
• 172693-83-3 1⁴-<4-phenyldiazenyl>-2,5,8,11-tetraoxa-1(1,2)-benzenacycloundecaphane 

Relevant articles and documents

Preparation method of icotinib key intermediate

The invention discloses a preparation method of an icotinib key intermediate, and belongs to the technical field of drug synthesis. According to the preparation method, triethylene glycol(p-toluene sulfonate) and N-Boc-3,4-dihydroxyl aniline are used as raw materials; the raw materials carry out crown ether cyclization reaction, halogenation reaction and amination reaction (amidation reaction), quinoline cyclization reaction, and chlorination reaction to obtain an icotinib key intermediate, namely 4-chloro-quinazoline[6.7-6]-12-crown-4; the newly designed synthesis route does not need a strongacid solution, which is required by a conventional synthesis route; the dangerous operation is avoided, the generation of a large amount of acidic waste liquid is avoided; and the novel synthesis route has the advantages of simple operation and high yield.