78563-03-8

Basic information

• Product Name: BIS(2-HYDROXY-5-BROMOPHENYL)METHANE
• Synonyms: BIS(2-HYDROXY-5-BROMOPHENYL)METHANE
• CAS NO: 78563-03-8
• Molecular Formula: C₁₃H₁₀Br₂O₂
• Molecular Weight: 358.03
• Mol File: 78563-03-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BIS(2-HYDROXY-5-BROMOPHENYL)METHANE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(2-HYDROXY-5-BROMOPHENYL)METHANE(78563-03-8)
• EPA Substance Registry System: BIS(2-HYDROXY-5-BROMOPHENYL)METHANE(78563-03-8)

Safety Data

• Hazardous Substances Data: 78563-03-8(Hazardous Substances Data)

Usage

Description

BIS(2-HYDROXY-5-BROMOPHENYL)METHANE, also known as 2,2''-Methylenebis(4-bromophenol), is a chemical compound derived from bromophenols found in the red alga Odonthalia corymbifera. It is characterized by its unique structure, which includes two hydroxyl groups and two bromine atoms attached to a central methane molecule. BIS(2-HYDROXY-5-BROMOPHENYL)METHANE exhibits potential antimicrobial properties and is utilized as an intermediate in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
BIS(2-HYDROXY-5-BROMOPHENYL)METHANE is used as an intermediate in the synthesis of Albuterol Dimer (A514515), which is an impurity of the drug Albuterol. Albuterol is a medication used to treat asthma and other respiratory conditions by relaxing the muscles in the airways and increasing air flow.
Additionally, due to its potential antimicrobial activity, BIS(2-HYDROXY-5-BROMOPHENYL)METHANE can be explored for use in:
Used in Antimicrobial Applications:
BIS(2-HYDROXY-5-BROMOPHENYL)METHANE can be employed as an antimicrobial agent, particularly against various types of bacteria and other microorganisms. Its unique structure and bromine content may contribute to its ability to disrupt cellular processes and inhibit microbial growth, making it a promising candidate for further research and development in the field of antimicrobial agents.

Upstream product

• 50-00-0 formaldehyd 
• 106-41-2 4-bromo-phenol 
• 2316-64-5 5-bromo-2-hydroxybenzyl alcohol 
• 7664-93-9 sulfuric acid 
• 2467-02-9 Bis(2-hydroxyphenyl)methane 

Downstream Products

• 2467-02-9 Bis(2-hydroxyphenyl)methane 
• 2212-47-7 2,2'-dimethoxy-5,5'-dibromodiphenylmethane 
• 83174-65-6 Acetic acid 2-(2-acetoxy-5-bromo-benzyl)-4-bromo-phenyl ester 
• 438246-20-9 4-Bromo-2-(5-bromo-2-hydroxy-benzyl)-6-hydroxymethyl-phenol 
• 438246-21-0 acetic acid 2-(2-acetoxy-5-bromo-benzyl)-6-acetoxymethyl-4-bromo-phenyl ester 
• 438246-22-1 acetic acid 2-acetoxymethyl-6-(2-acetoxy-5-vinyl-benzyl)-4-vinyl-phenyl ester 
• 438246-24-3 acetic acid 2-acetoxymethyl-6-(2-acetoxy-5-oxiranyl-benzyl)-4-oxiranyl-phenyl ester 
• 438246-23-2 acetic acid 2-[2-acetoxy-5-(2-bromo-1-hydroxy-ethyl)-benzyl]-6-acetoxymethyl-4-(2-bromo-1-hydroxy-ethyl)-phenyl ester 
• 149222-15-1 salbutamol dimer 
• 5578-67-6 3,3'-dicarboxy-2,2'-dihydroxydiphenylmethane 
• 35232-55-4 5,5'-dibromo-3,3'-dicarboxy-2,2'-dihydroxydiphenylmethane 
• 83143-21-9 Acetic acid 2-(2-acetoxy-5-bromo-benzoyl)-4-bromo-phenyl ester 
• 83143-04-8 1-[3-(3-Acetyl-5-bromo-2-hydroxy-benzyl)-5-bromo-2-hydroxy-phenyl]-ethanone 
• 83143-07-1 1-[3-(3-Acetyl-5-bromo-2-hydroxy-benzoyl)-5-bromo-2-hydroxy-phenyl]-ethanone 

Relevant articles and documents

ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF

Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.

Synthesis of a salbutamol dimer

First synthesis of the diastereomeric mixture of Salbutamol dimer (2) is described. The synthesis provides access to multi-gram quantities of 2 for reference supplies and further analytical and toxicology investigations. It also confirmed the proposed str

The Synthesis of Polyfunctional Aromatic Ring Systems. Structural Analogues of Phloroglucides, Aranciamycin, Cryptosporin and Terramycin

The synthesis of the title compounds is described.Some of the compounds prepared were found to be active against a number of pathogenic microorganisms in vitro.