78617-10-4

Basic information

• Product Name: JB 1-0
• Synonyms: JB 1-0
• CAS NO: 78617-10-4
• Molecular Formula: C₁₇H₂₂BrNO₃
• Molecular Weight: 368.26548
• Mol File: 78617-10-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 448.8°C at 760 mmHg
• Flash Point: 225.2°C
• Appearance: /
• Density: 1.4g/cm³
• Vapor Pressure: 3.01E-08mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: JB 1-0(CAS DataBase Reference)
• NIST Chemistry Reference: JB 1-0(78617-10-4)
• EPA Substance Registry System: JB 1-0(78617-10-4)

Safety Data

• Hazardous Substances Data: 78617-10-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H22BrNO3/c1-21-16-9-13(14(18)10-17(16)22-2)15-8-12(20)7-11-5-3-4-6-19(11)15/h9-11,15H,3-8H2,1-2H3

Upstream product

• 110-89-4 piperidine 
• 2156-71-0 N-chloropiperidine 
• 522-33-8 Tripiperidin 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 1248344-20-8 (E)-tert-butyl 2-(4-(2-bromo-4,5-dimethoxyphenyl)-2-oxobut-3-enyl)piperidine-1-carboxylate 

Relevant articles and documents

Biomimetic Organocatalytic Approach to 4-Arylquinolizidine Alkaloids and Application in the Synthesis of (-)-Lasubine II and (+)-Subcosine II

An enantioselective, biomimetic organocatalytic synthesis of 4-arylquinolizidin-2-ones, key intermediates in the synthesis of several Lythraceae alkaloids, was developed. The methodology features S-proline-mediated Mannich/aza-Michael reactions of readily available arylideneacetones and Δ1-piperideine. The total syntheses of (-)-lasubine II and (+)-subcosine II as well as the formal syntheses of structurally related Lythraceae alkaloids were achieved. The use of Δ1-pyrroline in the Mannich/aza-Michael reaction provides enantiomerically enriched 5-arylindolizidin-7-ones, which are precursors to nonopiate antinociceptive agents.

Total synthesis of (±) vertaline

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