78645-47-3Relevant articles and documents
Synthesis of thienospiran derivatives and studies of regioselectivity in Friedel-Crafts acylation reaction
Sen,Saha, Uttam Kumar,Das, Tulika
, p. 648 - 656 (2007/10/03)
Syntheses of several spiro[benzo[b]thiophen-6(5H),1'-cycloalkan]-4(7H)- ones (Type A) and spiro[benzo[b]thiophen-5,1'-cycloalkan]-4(5H)-ones (Type B) and their 2-alkyl derivatives are described. The regioselectivity in the Friedel-Crafts acylation of thiophenes with anhydride of various unsymmetrically substituted succinic acid having substituent(s) at the same carbon atom in two different solvents namely dichloromethane and nitrobenzene is studied. A plausible explanation of such regioselective acylation of thiophenes has been incorporated.