786710-30-3

Basic information

• Product Name: 12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (6-hydroxy-hexyl)-amide
• CAS NO: 786710-30-3
• Molecular Weight: 617.869
• Mol File: 786710-30-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (6-hydroxy-hexyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (6-hydroxy-hexyl)-amide(786710-30-3)
• EPA Substance Registry System: 12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid (6-hydroxy-hexyl)-amide(786710-30-3)

Safety Data

• Hazardous Substances Data: 786710-30-3(Hazardous Substances Data)

Upstream product

• 4048-33-3 6-amino-1-hexanol 
• 253877-42-8 12-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-dodecanoic acid 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 505-95-3 12-hydroxydodecanoic acid 

Relevant articles and documents

Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells

Double-stranded short interfering RNAs (siRNAs) mediate post-transcriptional inhibition of gene expression in a variety of biological systems. However, human liver cells show poor uptake of these nucleic acids. In order to improve the delivery of siRNA into these cells without transfection agents, we have synthesized two series of lipophilic siRNAs conjugated with derivatives of cholesterol, lithocholic acid or lauric acid. The lipid moieties were covalently linked to the 5′-ends of the RNAs using phosphoramidite chemistry. The potency of these chemically modified siRNAs to inhibit reporter gene expression was further investigated in vitro with β-galactosidase expressing liver cells.