78703-55-6

Basic information

• Product Name: methyl 1,3-dimethyl-1H-pyrazole-4-carboxylate
• Synonyms: methyl 1,3-dimethyl-1H-pyrazole-4-carboxylate
• CAS NO: 78703-55-6
• Molecular Formula: C7H10N2O2
• Molecular Weight: 154.17
• EINECS: -0
• Mol File: 78703-55-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 1,3-dimethyl-1H-pyrazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1,3-dimethyl-1H-pyrazole-4-carboxylate(78703-55-6)
• EPA Substance Registry System: methyl 1,3-dimethyl-1H-pyrazole-4-carboxylate(78703-55-6)

Safety Data

• Hazardous Substances Data: 78703-55-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 78703-53-4 1,3-dimethyl-1H-pyrazole-4-carboxylic acid 
• 25016-12-0 1,3-dimethyl-1H-pyrazole-4-carbaldehyde 
• 137024-37-4 methyl 2-(ethoxymethylene)-3-oxobutanoate 
• 60-34-4 methylhydrazine 

Downstream Products

• 78703-57-8 1,3-dimethyl-5-iodopyrazole-4-carboxylic acid methyl ester 
• 78703-61-4 1,3-Dimethyl-6-phenyl-1H-pyrano[4,3-c]pyrazol-4-one 

Relevant articles and documents

Toward Continuous-Flow Synthesis of Biologically Interesting Pyrazole Derivatives

A two-step continuous-flow synthesis of substituted pyrazole derivatives has been developed via the formation of vinylidene keto esters as key intermediates. Heterogeneous Ni2+-montmorillonite was found to be an efficient catalyst for orthoester condensation of 1,3-dicarbonyls under flow conditions. The intermediate reacted with methylhydrazine to afford pyrazole derivatives, for which suitable selection of a solvent played a key role in achieving high yields and excellent regioselectivities of the desired products. An application of this protocol has been demonstrated by the synthesis of a key intermediate for biologically active pyrazoles such as Bixafen. (Figure presented.).