78715-58-9 Usage
Description
Tetraethyl Difluoromethylenebisphosphonate is a pale yellow liquid that serves as an intermediate in the synthesis of various compounds, specifically 5'-diphosphate and 5'-triphosphate mimics. These mimics are crucial for the inhibition of transcriptase and glycerol kinase, making Tetraethyl Difluoromethylenebisphosphonate a significant component in the development of pharmaceuticals and other related applications.
Uses
Used in Pharmaceutical Industry:
Tetraethyl Difluoromethylenebisphosphonate is used as an intermediate for the synthesis of 5'-diphosphate and 5'-triphosphate mimics for the inhibition of transcriptase and glycerol kinase. This application is essential in the development of drugs targeting specific enzymes and pathways involved in various diseases and conditions.
Used in Research and Development:
In the field of research and development, Tetraethyl Difluoromethylenebisphosphonate is utilized as a key component in the synthesis of novel compounds and molecules. Its role in creating mimics for transcriptase and glycerol kinase inhibition makes it a valuable tool for scientists and researchers working on the discovery and development of new drugs and therapies.
Used in Chemical Synthesis:
Tetraethyl Difluoromethylenebisphosphonate is also used in chemical synthesis as a versatile building block for creating a wide range of compounds. Its unique chemical properties and reactivity make it a valuable asset in the synthesis of various molecules with potential applications in different industries, including pharmaceuticals, materials science, and more.
Check Digit Verification of cas no
The CAS Registry Mumber 78715-58-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,7,1 and 5 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 78715-58:
(7*7)+(6*8)+(5*7)+(4*1)+(3*5)+(2*5)+(1*8)=169
169 % 10 = 9
So 78715-58-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H20F2O6P2/c1-5-14-18(12,15-6-2)9(10,11)19(13,16-7-3)17-8-4/h5-8H2,1-4H3
78715-58-9Relevant articles and documents
ATP analogs with non-transferable groups in the γ position as inhibitors of glycerol kinase
Bystrom, Cory E.,Pettigrew, Donald W.,Remington, S. James,Branchaud, Bruce P.
, p. 2613 - 2616 (1997)
β,γ-Difluoromethyleneadenosine-5'-triphos (AMP-PCF2P, 3) and γ-arsono-β,γ-methyleneadenosined'-diphosphate (AMP-PCAs, 4) were synthesized and were found to be competitive inhibitors of glycerolkinase. Commercially available AMP-PCP and AMP-PNP also are competitive inhibitors. The structural similarities and differences of these ATP analogs and their effect on kinase inhibition are discussed.
Synthesis of new PMEA diphosphate mimics
Laux,Perigaud,Imbach,Gosselin
, p. 1003 - 1004 (2007/10/03)
We synthesized and characterized new diphosphate mimics of the acyclic nucleotide phosphonate PMEA [Adefovir, 9-(2-phosphonylmethoxyethyl)adenine].
Synthesis of a potent inhibitor of HIV reverse transcriptase
Hamilton, Chris J.,Roberts, Stanley M.,Shipitsin, Alexander
, p. 1087 - 1088 (2007/10/03)
The newly synthesised P(β),-P(γ)-difluoromethylenebisphosphonate analogue 2 of nor-carbovir triphosphate is a potent inhibitor of HIV reverse transcriptase; it also exhibits a greatly enhanced stability to dephosphorylation, in foetal blood serum, relative to AZTTP and other nucleoside triphosphates.
