78750-68-2

Basic information

• Product Name: 4-[(3-AMINOPYRIDIN-2-YL)AMINO]PHENOL
• Synonyms: 4-[(3-AMINOPYRIDIN-2-YL)AMINO]PHENOL;4-[(3-Amino-2-pyridinyl)amino]phenol
• CAS NO: 78750-68-2
• Molecular Formula: C₁₁H₁₁N₃O
• Molecular Weight: 201.22
• Mol File: 78750-68-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[(3-AMINOPYRIDIN-2-YL)AMINO]PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(3-AMINOPYRIDIN-2-YL)AMINO]PHENOL(78750-68-2)
• EPA Substance Registry System: 4-[(3-AMINOPYRIDIN-2-YL)AMINO]PHENOL(78750-68-2)

Safety Data

• Hazardous Substances Data: 78750-68-2(Hazardous Substances Data)

Usage

Description

4-[(3-aminopyridin-2-yl)amino]phenol, also known as A-666, is a chemical compound with the molecular formula C11H10N4O. It is a potent and selective inhibitor of BRD4, a protein involved in the regulation of gene expression and cell growth. A-666 has been used in research to study the role of BRD4 in various diseases, including cancer and inflammatory disorders. It has also shown potential for the development of new treatments for these conditions. A-666 is a promising compound with therapeutic potential and continues to be the subject of ongoing scientific investigation.

Uses

Used in Pharmaceutical Industry:
4-[(3-aminopyridin-2-yl)amino]phenol is used as a research compound for studying the role of BRD4 in various diseases, such as cancer and inflammatory disorders. Its potent and selective inhibition of BRD4 makes it a valuable tool in understanding the underlying mechanisms of these conditions and identifying potential therapeutic targets.
Used in Drug Development:
4-[(3-aminopyridin-2-yl)amino]phenol is used as a starting point for the development of new treatments for diseases involving BRD4 dysregulation. Its potential as a therapeutic agent has been demonstrated in preclinical studies, and ongoing research aims to further explore its efficacy and safety in treating various conditions.
Used in Academic Research:
4-[(3-aminopyridin-2-yl)amino]phenol is used as a research tool in academic institutions to investigate the molecular mechanisms of BRD4 and its role in gene regulation and cell growth. This knowledge can contribute to a better understanding of the pathophysiology of diseases associated with BRD4 and aid in the discovery of novel therapeutic strategies.

Upstream product

• 78750-61-5 4-[(3-nitropyridin-2-yl)amino]phenol 
• 5470-18-8 2-Chloro-3-nitropyridine 
• 123-30-8 4-amino-phenol 

Downstream Products

• 141430-65-1 N-[2-(4-hydroxy-phenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide 
• 141449-98-1 4-Methoxy-N-[2-[[4-(4-methoxybenzenesulfonyloxy)phenyl]amino]-3-pyridyl]benzenesulfonamide 
• 141450-48-8 N-[2-(4-hydroxy-phenylamino)-pyridin-3-yl]-4-methoxy-benzenesulfonamide hydrochloride 

Relevant articles and documents

Synthesis and biological evaluation of 1-benzyl-N-(2-(phenylamino)pyridin-3-yl)-1H-1,2,3-triazole-4-carboxamides as antimitotic agents

A library of 1-benzyl-N-(2-(phenylamino)pyridin-3-yl)-1H-1,2,3-triazole-4-carboxamides (7a–al) have been designed, synthesized and screened for their anti-proliferative activity against some selected human cancer cell lines namely DU-145, A-549, MCF-7 and HeLa. Most of them have shown promising cytotoxicity against lung cancer cell line (A549), amongst them 7f was found to be the most potent anti-proliferative congener. Furthermore, 7f exhibited comparable tubulin polymerization inhibition (IC50 value 2.04 μM) to the standard E7010 (IC50 value 2.15 μM). Moreover, flow cytometric analysis revealed that this compound induced apoptosis via cell cycle arrest at G2/M phase in A549 cells. Induction of apoptosis was further observed by examining the mitochondrial membrane potential and was also confirmed by Hoechst staining as well as Annexin V-FITC assays. Furthermore, molecular docking studies indicated that compound 7f binds to the colchicine binding site of the β-tubulin. Thus, 7f exhibits anti-proliferative properties by inhibiting the tubulin polymerization through the binding at the colchicine active site and by induction of apoptosis.

Crystalline N-(2-((4-hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide hydrochloride

Crystalline N-(2-((4-hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide hydrochloride, ways to make it, compositions containing it and methods of treatment of diseases using it are disclosed.

N-((2Z)-2-((4-HYDROXYPHENYL)IMINO)-1,2-DIHYDRO-3-PYRIDINYL)-4-METHOXYBENZENESULFONAMIDE CRYSTALLINE FORM 2

N-((2Z)-2-((4-Hydroxyphenyl)imino)-1,2-dihydro-3-pyridinyl)-4-methoxybenzenesulfonamide Crystalline Form 2, ways to make it, compositions containing it and methods of treatment of diseases using it are disclosed.