78808-04-5Relevant articles and documents
Novel Mannich Reaction of 8-Acetyl-7-hydroxy-4-methylcoumarin with 1-Arylpiperazines
Samant, S. D.,Deodhar, K. D.,Kulkarni, R. A.
, p. 215 - 217 (2007/10/02)
8-Acetyl-7-hydroxy-4-methylcoumarin (I) reacts with 1-arylpiperazines in the presence of excess paraformaldehyde to yield 4-methyl-9-(4-aryl-1-piperazinylmethyl)-2H,10H-8,9-dihydrobenzodipyran-2,10-diones, instead of the Mannich bases (II) or (III).The compounds show action on smooth muscles and act as agonists to the heart muscle receptors.