78858-44-3 Usage
Description
1-O-HEXADECYL-2-O-METHYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE, also known as 2-O-methyl PAF C-16, is a synthetic PAF analog that contains a methyl group attached by an ether linkage at the sn-2 position. Although its biological activities have not been well characterized, the C-18 analog has been shown to mediate a number of biological responses, including decreasing plasma membrane fluidity and inhibiting tumor cell invasiveness in embryonic chick heart. In rat astrocytes, the C-18 analog causes the release of large quantities of NO by a pathway involving activation of NOS.
Uses
Used in Pharmaceutical Industry:
1-O-HEXADECYL-2-O-METHYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE is used as a potential therapeutic agent for various applications, including decreasing plasma membrane fluidity and inhibiting tumor cell invasiveness. Its C-18 analog has demonstrated these effects in embryonic chick heart, making it a promising candidate for further research and development in the pharmaceutical industry.
Used in Neuroscience Research:
1-O-HEXADECYL-2-O-METHYL-SN-GLYCERYL-3-PHOSPHORYLCHOLINE is used as a research tool in neuroscience to study the effects of its C-18 analog on the release of nitric oxide (NO) in rat astrocytes. This helps researchers understand the underlying mechanisms and pathways involved in NO production and its role in various neurological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 78858-44-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,8,5 and 8 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 78858-44:
(7*7)+(6*8)+(5*8)+(4*5)+(3*8)+(2*4)+(1*4)=193
193 % 10 = 3
So 78858-44-3 is a valid CAS Registry Number.
InChI:InChI=1/C25H54NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-30-23-25(29-5)24-32-33(27,28)31-22-20-26(2,3)4/h25H,6-24H2,1-5H3/t25-/m1/s1
78858-44-3Relevant articles and documents
Antitumor phospholipids: A one-pot introduction of a phosphocholine moiety into lipid hydroxy acceptors
Erukulla, Ravi Kumar,Byun, Hoe-Sup,Bittman, Robert
, p. 5783 - 5784 (2007/10/02)
A high-yielding, 3-step, one-pot conversion of lipid hydroxy acceptors 2 into clinically useful alkylphosphocholines 1 is reported. Reaction of 2 with ethylene chlorophosphite gave phosphite 3, which underwent oxidation and ring opening with bromine in CH2Cl2 to give (2-bromoethyl)phosphate ester 4; hydrolysis of the P-Br bond and quaternization of 4 with aqueous trimethylamine generated 1.
Stereospecific Synthesis of Ether and Thioether Phospholipids. The Use of L-Glyceric Acid as a Chiral Phospholipid Precursor
Bhatia, Suresh K.,Hajdu, Joseph
, p. 5034 - 5039 (2007/10/02)
A novel stereospecific synthesis of biologically active ether phospholipids is reported.The synthesis is based on (1) the use of L-glyceric acid as the chiral center for the construction of the optically active phospholipid molecule, (2) the introduction
An enantioselective synthesis of platelet-activating factors, their enantiomers, and their analogues from D- and L-tartaric acids
Ohno,Fujita,Nakai,Kobayashi,Inoue,Nojima
, p. 572 - 582 (2007/10/02)
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