78861-25-3

Basic information

• Product Name: 3-OXO-4-P-TOLYL-BUTYRIC ACID METHYL ESTER
• Synonyms: 3-OXO-4-P-TOLYL-BUTYRIC ACID METHYL ESTER;4-(4-Methylphenyl)-3-oxobutyric acid;4-(4-METHYLPHENYL)-3-OXOBUTYRIC ACID METHYL ESTER;4-METHYL-BETA-OXO-BENZENEBUTANOIC ACID METHYL ESTER;Methyl 4-(4-methylphenyl)-3-oxobutanoate
• CAS NO: 78861-25-3
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.24
• Mol File: 78861-25-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-OXO-4-P-TOLYL-BUTYRIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-OXO-4-P-TOLYL-BUTYRIC ACID METHYL ESTER(78861-25-3)
• EPA Substance Registry System: 3-OXO-4-P-TOLYL-BUTYRIC ACID METHYL ESTER(78861-25-3)

Safety Data

• Hazardous Substances Data: 78861-25-3(Hazardous Substances Data)

Upstream product

• 78861-21-9 cis-Methyl 3,4-epoxy-4-(4'-methylphenyl)butanoate 
• 78861-26-4 Methyl 4-chloro-3-hydroxy-4-(4'-methylphenyl)butanoate 
• 4619-20-9 3-(4-methylbenzoyl)propionic acid 
• 57498-54-1 methyl 4-(4-methylphenyl)-4-oxobutanoate 
• 78861-19-5 Methyl 3-bromo-4-keto-4-(4'-methylphenyl)butanoate 
• 79-20-9 acetic acid methyl ester 
• 35675-44-6 4-methylphenylacetyl chloride 

Downstream Products

• 2096-86-8 p-Tolylaceton 
• 1137829-49-2 C₁₅H₂₂O₃Si 
• 270062-95-8 (R)-3-amino-4-p-tolylbutanoic acid 

Relevant articles and documents

Discovery of [1,2,4]-triazolo [1,5-a]pyrimidine-7(4H)-one derivatives as positive modulators of GABAA1 receptor with potent anticonvulsant activity and low toxicity

In searching for more effective and safer antiepileptic drugs, a series of 2,5-disubstituted [1,2,4]-triazolo[1,5-a]pyrimidine-7(4H)-one derivatives were designed and synthesized. Spontaneous Ca2+ oscillations (SCOs) of cortical neurons were used for in vitro phenotypic screening. Maximal electroshock test (MES) and pentylenetetrazole (PTZ) test were used to access their anticonvulsant activity, and rotarod test was used to estimate their neurotoxicity. The active compounds in in vitro model are specifically effective in pentylenetetrazole (PTZ)-induced epilepsy model but not maximal electroshock (MES) model, more importantly with lower neurotoxicity as compared to commonly used drugs. Among them, compound 5c and 5e showed significant anticonvulsant activities in PTZ-induced epilepsy model with ED50 values at 31.81 mg/kg and 40.95 mg/kg, respectively. These compounds have improved neurotoxicity with protective index (PI = TD50/ED50) values at 17.22 and 9.09, respectively. Finally we demonstrated that compound 5c and 5e mainly acted on GABAA receptor as positive modulators but not sodium channels. Thus the present study has provided potential candidates for further investigation in epilepsy.

ESTERS AND AMIDES AS PLA2 INHIBITORS

The present invention relates to a novel fatty acid derivative of formula (I), wherein R1 is acyl group; R2 is acyl(lower)alkyl; R3 is hydrogen, aryl(lower)alkyl, etc.; R4 is acyl(lower)alkyl; and X is —O—, —NH—