78880-65-6

Basic information

• Product Name: 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carbonitrile
• Synonyms: 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carbonitrile
• CAS NO: 78880-65-6
• Molecular Formula: C₁₅H₁₀N₂O
• Molecular Weight: 234.2527
• EINECS: 278-998-4
• Mol File: 78880-65-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 458.982°C at 760 mmHg
• Flash Point: 231.384°C
• Appearance: /
• Density: 1.321g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.683
• CAS DataBase Reference: 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carbonitrile(78880-65-6)
• EPA Substance Registry System: 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carbonitrile(78880-65-6)

Safety Data

• Hazardous Substances Data: 78880-65-6(Hazardous Substances Data)

Usage

Primary Uses

Epilepsy, bipolar disorder, and trigeminal neuralgia treatment

Mechanism of Action

Stabilizes electrical activity in the brain, affects neurotransmitters and sodium channels

Drug Classification

Anticonvulsant and mood-stabilizing drug

Prescription Purpose

Control seizures, manage mood swings in bipolar disorder patients

Potential Side Effects

Dizziness, drowsiness, gastrointestinal disturbances

Monitoring Requirement

Blood levels to ensure therapeutic efficacy and minimize adverse effects risk

Administration Route

Oral

InChI:InChI=1/C15H10N2O/c16-10-17-13-7-3-1-5-11(13)9-15(18)12-6-2-4-8-14(12)17/h1-8H,9H2

Upstream product

• 110-80-5 2-ethoxy-ethanol 
• 78880-63-4 5-cyano-10-nitro-5H-dibenz[b,f]azepine 
• 7439-89-6 iron 
• 42787-75-7 5-cyanodibenzazepine 

Downstream Products

• 391670-48-7 2-(5-oxo-6H-indolo[1,2-a]quinazolin-7-yl)acetic acid 
• 28721-07-5 oxcarbazepine 

Relevant articles and documents

Iron-Catalyzed Wacker-type Oxidation of Olefins at Room Temperature with 1,3-Diketones or Neocuproine as Ligands**

Herein, we describe a convenient and general method for the oxidation of olefins to ketones using either tris(dibenzoylmethanato)iron(III) [Fe(dbm)3] or a combination of iron(II) chloride and neocuproine (2,9-dimethyl-1,10-phenanthroline) as catalysts and phenylsilane (PhSiH3) as additive. All reactions proceed efficiently at room temperature using air as sole oxidant. This transformation has been applied to a variety of substrates, is operationally simple, proceeds under mild reaction conditions, and shows a high functional-group tolerance. The ketones are formed smoothly in up to 97 % yield and with 100 % regioselectivity, while the corresponding alcohols were observed as by-products. Labeling experiments showed that an incorporated hydrogen atom originates from the phenylsilane. The oxygen atom of the ketone as well as of the alcohol derives from the ambient atmosphere.

5-Cyano-10-hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine, processes for its preparation and for its conversion into 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine or into 5-carbamoyl-5H-dibenz[b,f]azepine

A process and intermediates useful for the preparation of carbamazepine and oxcarbamazepine are disclosed.