78888-57-0

Basic information

• Product Name: 1-(4-methoxyphenyl)-2-(piperidin-1-ylmethyl)prop-2-en-1-one
• CAS NO: 78888-57-0
• Molecular Formula: C₁₆H₂₁NO₂
• Molecular Weight: 259.3434
• Mol File: 78888-57-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 398.6°C at 760 mmHg
• Flash Point: 194.9°C
• Density: 1.052g/cm³
• Vapor Pressure: 1.46E-06mmHg at 25°C
• Refractive Index: 1.532
• CAS DataBase Reference: 1-(4-methoxyphenyl)-2-(piperidin-1-ylmethyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-2-(piperidin-1-ylmethyl)prop-2-en-1-one(78888-57-0)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-2-(piperidin-1-ylmethyl)prop-2-en-1-one(78888-57-0)

Safety Data

• Hazardous Substances Data: 78888-57-0(Hazardous Substances Data)

Usage

Chemical structure

Contains a piperidine ring and a propenone group

Classification

Heterocyclic compound

Potential pharmacological properties

Interactions with receptors in the central nervous system, leading to psychoactive or neurological effects

Presence of functional groups

Aromatic ring (4-methoxyphenyl), amine group (piperidin-1-ylmethyl), and carbonyl group (prop-2-en-1-one)

Potential applications

Pharmaceuticals, neuroscience, and organic synthesis

Synthetic intermediate

May serve as a building block for the synthesis of other compounds

Molecular weight

Approximately 283.38 g/mol

Physical state

Likely a solid at room temperature, based on the presence of multiple rings and a relatively high molecular weight

Solubility

Likely soluble in organic solvents such as ethanol, methanol, or acetone, due to the presence of the aromatic ring and the carbonyl group

Stability

May be sensitive to heat, light, or moisture, as many organic compounds with aromatic rings and amine groups are

Reactivity

Could potentially react with nucleophiles, electrophiles, or other reactive species, depending on the reaction conditions and the specific reagents used.

Upstream product

• 110-88-3 1,3,5-Trioxan 
• 6091-44-7 piperidine hydrochloride 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Relevant articles and documents

N-substituted alpha-aminoalkylacrylophenones and some related compounds: a new class of spermicidal agents.

The results of a screening program to test the spermicidal effectiveness of several compounds is presented. The program was initiated after N-substituted 3-aminoacrylophenones were found to have unexpected spermicidal activity. The compounds had been synthesized as possible antiinflammatory agents. This result prompted the synthesis and screening of N-substituted alpha-aminomethylacrylophenones, alpha-(2-aminomethyl)acrylophenones and 3-N-substituted-2-methyleneindan-1-ones. The starting materials, substituted acetophenones, for the synthesis of N-substituted alpha-aminomethylacrylophenones were either commercial products or obtained by standard methods. N-substituted amino-butyrophenone was reacted with paraformaldehyde to yield the alpha-(2 aminoethyl)acrylophenones. A series of reactions was undertaken to synthesize 2-methyleneindan-1-ones. The preparation of each is detailed and molecular formulas are provided. Spermicidal activity was assessed by dissolving the compound in physiological saline at different concentrations. 2 drops of rat sperm suspension or human semen were placed on a slide, followed by 2 drops of a compound solution. Control slides of physiological saline were prepared. The contents were mixed for approximately 5 seconds and examined under a phase contrast microscope. The results were considered positive if 100% of the spermatozoa became immotile instantaneously. Several of the compounds showed marked spermicidal activity.