78892-77-0 Usage
Description
(1H-IMIDAZOL-4-YL)-P-TOLYL-METHANONE is a chemical compound characterized by the molecular formula C11H11N3O. It is a ketone derivative that features an imidazole ring and a tolyl group, which contribute to its potential biological activities and chemical versatility. (1H-IMIDAZOL-4-YL)-P-TOLYL-METHANONE is recognized for its role in the pharmaceutical industry, where it serves as a valuable building block for the synthesis of a variety of biologically active compounds, including those with potential as drug candidates.
Uses
Used in Pharmaceutical Industry:
(1H-IMIDAZOL-4-YL)-P-TOLYL-METHANONE is utilized as a key component in the development of biologically active molecules due to its imidazole ring, which has been studied for antifungal, antiviral, and antibacterial properties. Its presence in drug candidates can contribute to a range of therapeutic effects.
Used in Drug Discovery and Medicinal Chemistry:
As a building block, (1H-IMIDAZOL-4-YL)-P-TOLYL-METHANONE is used for the synthesis of new compounds with potential medicinal applications. The p-tolyl group in the compound provides a functional handle that allows for further chemical modifications, enhancing its utility in creating diverse and effective pharmaceutical agents.
Check Digit Verification of cas no
The CAS Registry Mumber 78892-77-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,8,9 and 2 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 78892-77:
(7*7)+(6*8)+(5*8)+(4*9)+(3*2)+(2*7)+(1*7)=200
200 % 10 = 0
So 78892-77-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N2O/c1-8-2-4-9(5-3-8)11(14)10-6-12-7-13-10/h2-7H,1H3,(H,12,13)
78892-77-0Relevant articles and documents
A General Route to 4-Substituted Imidazoles
Katritzky, Alan R.,Slawinski, Jaroslaw J.,Brunner, Frederic,Gorun, Sergiu
, p. 1139 - 1145 (2007/10/02)
Literature routes to di(imidazol-4-yl)methanol (1a) dinitrate and tri(imidazol-4-yl)methanol (2a) trihydrochloride were improved to give 32 and 16percent overall yields, respectively; but we failed to synthesize bis- (1b) and tris-(1-methylimidazol-4-yl)methanol (2b) by the methylation of the corresponding N-methoxymethyl compounds (3; x=2 and x=3).Attempted 4-lithiation of the 1,2,5-protected imidazole (4a) with BuLi-TMEDA failed, giving after hydrolysis 1-methyl-5-trimethylsilylimidazole (4b); similar failures were observed for 2,5-dicarboxy-1-methylimidazole, which after metallation with BuLi-TMEDA and hydrolysis afforded 1-methylimidazole-5-carboxylic acid (5).Our attempts to obtain 4-bromo-1-methylimidazole (10a) and 4-bromo-1-ethylimidazole suitable for a halogen-lithium exchange or for Grignard reaction also failed.Attempted selective lithiation of 2-phenylthio-1-tritylimidazole (16) at the 4-position, then theatment with ethyl formate, led only to a mixture of 4- and 5-substituted products in very low yield, and 1-diethoxymethyl-2-phenylthioimidazole (18) was unstable and difficult to purify. 4-Bromoimidazole with two mol equiv. of t-butyl-lithium gives 1,4-dilithioimidazole, which is now shown to provide a general route to 4-substituted imidazoles.
