789445-02-9

Basic information

• Product Name: 6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
• Synonyms: 6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
• CAS NO: 789445-02-9
• Molecular Weight: 370.448
• Mol File: 789445-02-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one(789445-02-9)
• EPA Substance Registry System: 6-hydroxy-8-(1-hydroxy-2-((2-methyl-4-phenylbutan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one(789445-02-9)

Safety Data

• Hazardous Substances Data: 789445-02-9(Hazardous Substances Data)

Upstream product

• 869478-09-1 8-acetyl-6-(phenylmethoxy)-4H-1,4-benzoxazin-3-one 
• 693273-07-3 6-(benzyloxy)-8-(2,2-dihydroxyacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 43052-72-8 1,1-Dimethyl-3-phenyl-propylamin 
• 79399-13-6 N-[1,1-dimethyl-3-phenylpropyl]acetamide 
• 103-05-9 4-phenyl-2-methyl-2-butanol 

Relevant articles and documents

Design, synthesis and biological evaluation of 8-(2-amino-1-hydroxyethyl)-6-hydroxy-1,4-benzoxazine-3(4H)-one derivatives as potent β2-adrenoceptor agonists

A series of β2-adrenoceptor agonists with an 8-(2-amino-1-hydroxyethyl)-6-hydroxy-1,4-benzoxazine-3(4H)-one moiety is presented. The stimulatory effects of the compounds on human β2-adrenoceptor and β1-adrenoceptor were characterized by a cell-based assay. Their smooth muscle relaxant activities were tested on isolated guinea pig trachea. Most of the compounds were found to be potent and selective agonists of the β2-adrenoceptor. One of the compounds, (R)-18c, possessed a strong β2-adrenoceptor agonistic effect with an EC50 value of 24 pM. It produced a full and potent airway smooth muscle relaxant effect same as olodaterol. Its onset of action was 3.5 min and its duration of action was more than 12 h in an in vitro guinea pig trachea model of bronchodilation. These results suggest that (R)-18c is a potential candidate for long-acting β2-AR agonists.