79009-37-3

Basic information

• Product Name: H-THR-NHME
• Synonyms: THREONINE-NHME;L-THREONINE METHYLAMIDE;L-THREONINE METHYLAMIDE HYDROCHLORIDE;H-THR-NHME;H-THR-NHME HCL;L-Thr-NHMe
• CAS NO: 79009-37-3
• Molecular Formula: C₅H₁₂N₂O₂
• Molecular Weight: 132.16
• Mol File: 79009-37-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• CAS DataBase Reference: H-THR-NHME(CAS DataBase Reference)
• NIST Chemistry Reference: H-THR-NHME(79009-37-3)
• EPA Substance Registry System: H-THR-NHME(79009-37-3)

Safety Data

• Hazardous Substances Data: 79009-37-3(Hazardous Substances Data)

Usage

General Description

H-THR-NHME is a peptide chemical compound consisting of the amino acid threonine (THR) linked to a methyl group (NHME) through a peptide bond. Threonine is a polar amino acid essential for the human diet, involved in protein synthesis and forming the structural and functional components of cells. The addition of the methyl group in H-THR-NHME introduces a hydrophobic property to the compound, potentially affecting its solubility and interactions with other molecules. This chemical compound may have applications in the development of novel peptides with specific properties for various biomedical and therapeutic purposes.

Upstream product

• 72-19-5 L-threonine 
• 74-89-5 methylamine 
• 1072136-18-5 C₁₀H₂₀N₂O₄ 
• 19647-69-9 benzyl ((2S,3R)-3-hydroxy-1-(methylamino)-1-oxobutan-2-yl)carbamate 

Downstream Products

• 141075-60-7 [(S)-1-((1S,2R)-2-Hydroxy-1-methylcarbamoyl-propylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester 
• 141075-62-9 [1-((1S,2R)-2-Hydroxy-1-methylcarbamoyl-propylcarbamoyl)-1-methyl-ethyl]-carbamic acid benzyl ester 
• 126530-41-4 (S)-3-Hydroxy-N-methyl-2-(3-phenyl-thioureido)-butyramide 
• 141075-55-0 Cbz-Glycyl-allo-threonine N-methyl amide 
• 141075-57-2 Cbz-glycyl-threonine N-methyl amide 
• 141075-64-1 Cbz-prolyl-threonine N-methyl amide 
• 141075-56-1 ((4S,5R)-5-Methyl-4-methylcarbamoyl-4,5-dihydro-oxazol-2-ylmethyl)-carbamic acid benzyl ester 
• 141194-97-0 [2-((2S,3S)-2-Methyl-3-methylcarbamoyl-aziridin-1-yl)-2-oxo-ethyl]-carbamic acid benzyl ester 
• 141075-61-8 [(S)-2-Methyl-1-((4S,5S)-5-methyl-4-methylcarbamoyl-4,5-dihydro-oxazol-2-yl)-propyl]-carbamic acid benzyl ester 
• 141075-63-0 [1-Methyl-1-((4S,5S)-5-methyl-4-methylcarbamoyl-4,5-dihydro-oxazol-2-yl)-ethyl]-carbamic acid benzyl ester 
• 141075-65-2 (S)-2-((4S,5S)-5-Methyl-4-methylcarbamoyl-4,5-dihydro-oxazol-2-yl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 141075-58-3 ((4S,5S)-5-Methyl-4-methylcarbamoyl-4,5-dihydro-oxazol-2-ylmethyl)-carbamic acid benzyl ester 

Relevant articles and documents

SPIRO-LACTAM NMDA MODULATORS AND METHODS OF USING SAME

Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.

Non-natural amino acids as modulating agents of the conformational space of model glycopeptides

The synthesis and conformational analysis in aqueous solution of different α-methyl-α-amino acid di-amides, derived from serine, threonine, β-hydroxycyclobutane-α-amino acids, and their corresponding model β-O-glucopeptides, are reported. The study reveals that the presence of an α-methyl group forces the model peptides to adopt helix-like conformations. These folded conformations are especially significant for cyclobutane derivatives. Interestingly, this feature was also observed in the corresponding model glucopeptides, thus indicating that the α-methyl group and not the β-O-glucosylation process largely determines the conformational preference of the backbone in these structures. On the other hand, atypical conformations of the glycosidic linkage were experimentally determined. Therefore, when a methyl group was located at the Cβ atom with an R configuration, the glycosidic linkage was rather rigid. Never-theless, when the S configuration was displayed, a significant degree of flexibility was observed for the glycosidic linkage, thus showing both alternate and eclipsed conformations of the ψb dihedral angle. In addition, some derivatives exhibited an unusual value for the Φ2 angle, which was far from a value of -60° expected for a conventional β-O-glycosidic linkage. In this sense, the different conformations exhibited by these molecules could be a useful tool in obtaining systems with conformational preferences "a la carte".