79023-55-5Relevant articles and documents
The Thiomethylation of Substituted Glutarimides
Seitz, David E.,Needham, Fang-Ling
, p. 687 - 689 (2007/10/02)
Conditions for the mono- and di(thiomethylation) of N-methyl-3-ethyl-3-phenylpiperidine-2,6-dione and the monomethylation of N-methyl-3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione, potential inhibitors of estrogen synthetase, are described and contrasted with a closely relative lactam, N-methylpiperidone.The inflence of solvent, base and electrophile on product distribution is explored.