79044-27-2Relevant articles and documents
Base-promoted lipase-catalyzed kinetic resolution of atropisomeric 1,1′-biaryl-2,2′-diols
Moustafa, Gamal A. I.,Kasama, Kengo,Higashio, Koichi,Akai, Shuji
, p. 1165 - 1175 (2019/01/23)
Herein we report a dramatic acceleration of the lipase-catalyzed kinetic resolution of atropisomeric 1,1′-biaryl-2,2′-diols by the addition of sodium carbonate. This result likely originates from the increased nucleophilicity of the phenolic hydroxyl group toward the acyl-enzyme intermediate. Under these conditions, various substituted C2-symmetric and non-C2-symmetric binaphthols and biphenols were efficiently resolved with ~50% conversion in only 13-30 h with excellent enantioselectivity.
BIFUNCTIONAL CHIRAL SYNTHONS VIA BIOCHEMICAL METHODS. VII. OPTICALLY-ACTIVE 2,2'-DIHYDROXY-1,1'-BINAPHTHYL.
Wu, Shih-Hsiung,Zhang, Li-Qing,Chen, Ching-Shih,Girdaukas, Gary,Sih, C. J.
, p. 4323 - 4326 (2007/10/02)
Optically-active binaphthols (1R and 1S) have been prepared via microbial enantiospecific hydrolysis of axially-disymmetric (+/-)-2,2'-diacetoxy-1,1'-binaphthyl.