79113-14-7Relevant articles and documents
Synthesis and evaluation of a novel 99mTc-labeled bioreductive probe for tumor hypoxia imaging
Kimura, Sadaaki,Umeda, Izumi O.,Moriyama, Noriyuki,Fujii, Hirofumi
, p. 7359 - 7362 (2011)
Tumor hypoxia is closely associated with the malignant progression and/or the high metastatic ability of tumors and often induces resistance to chemo- and/or radiotherapy. Thus, the detection and evaluation of hypoxia is important for the optimization of
SYTHESIS OF RENIN INHIBITORS INVOLVING A CYCLOADDITION REACTION
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Page/Page column 41, (2010/11/26)
The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula (III), wherein R, R1, and R' are as defined in the specification, or a salt thereof, and a compound of formula (IV) wherein R, R1, R2 and R' are as defined in the specification, and processes of manufacturing these.