79130-51-1

Basic information

• Product Name: (3-CHLORO-3-PHENYL-PROPYL)-DIMETHYL-AMINE HYDROCHLORIDE
• Synonyms: (3-CHLORO-3-PHENYL-PROPYL)-DIMETHYL-AMINE HYDROCHLORIDE;(3-Choro-3-phenyl-propyl)-dimethyl-amine hydrochloride;N-(3-chloro-3-phenylpropyl)-N,N-dimethylamine;(3-Chloro-3-phenyl-propyl)-dimethyl-amine
• CAS NO: 79130-51-1
• Molecular Formula: C₁₁H₁₆ClN
• Molecular Weight: 234.17
• Mol File: 79130-51-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 176 °C
• Boiling Point: 261.7±33.0 °C(Predicted)
• Appearance: /
• Density: 1.034±0.06 g/cm3(Predicted)
• PKA: 9.16±0.28(Predicted)
• CAS DataBase Reference: (3-CHLORO-3-PHENYL-PROPYL)-DIMETHYL-AMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-CHLORO-3-PHENYL-PROPYL)-DIMETHYL-AMINE HYDROCHLORIDE(79130-51-1)
• EPA Substance Registry System: (3-CHLORO-3-PHENYL-PROPYL)-DIMETHYL-AMINE HYDROCHLORIDE(79130-51-1)

Safety Data

• Hazardous Substances Data: 79130-51-1(Hazardous Substances Data)

Usage

General Description

(3-Chloro-3-phenyl-propyl)-dimethyl-amine hydrochloride is a chemical compound that is commonly used as a reagent in organic synthesis and medicinal chemistry. It is a quaternary ammonium salt, which means it contains a positively charged nitrogen atom. This chemical is often used as a reducing agent, as well as in the production of pharmaceuticals and dyes. It is also used in the synthesis of various organic compounds, including those used in the manufacturing of pesticides and herbicides. Additionally, (3-Chloro-3-phenyl-propyl)-dimethyl-amine hydrochloride has been studied for its potential as a chiral auxiliary in asymmetric synthesis reactions.

Upstream product

• 5554-64-3 N,N-dimethyl-3-hydroxy-3-phenylpropylamine 
• 98-86-2 acetophenone 
• 3506-36-3 3-dimethylaminopropiophenone 

Downstream Products

• 136436-90-3 Dimethyl-[3-(naphthalen-1-ylsulfanyl)-3-phenyl-propyl]-amine 
• 136436-89-0 N,N-dimethyl-3-(2-methoxyphenylthio)-3-phenylpropylamine 
• 136436-87-8 Dimethyl-[3-phenyl-3-(4-trifluoromethyl-phenylsulfanyl)-propyl]-amine 
• 128036-36-2 Methyl-(3-phenyl-3-o-tolylsulfanyl-propyl)-amine 
• 128036-33-9 N-methyl-3-(2-methoxyphenylthio)-3-phenylpropylamine 
• 136436-91-4 Methyl-[3-(naphthalen-1-ylsulfanyl)-3-phenyl-propyl]-amine 
• 128036-38-4 UN⁽¹⁰⁰⁾C₁₀₀₁₆A 
• 83015-25-2 N,N-dimethyl-3-(2-methyl-phenyloxy)-3-phenyl-propanamine 
• 1584114-14-6 6-((3-(dimethylamino)-1-phenylpropyl)thio)pyridin-3-amine 
• 1584114-15-7 phenyl (6-((3-(dimethylamino)-1-phenylpropyl)thio)pyridin-3-yl)carbamate 
• 1584113-95-0 N-(6-((3-(dimethylamino)-1-phenylpropyl)thio)pyridine-3-yl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide 
• 1584114-13-5 N,N-dimethyl-3-((5-nitropyridin-2-yl)thio)-3-phenylpropan-1-amine 
• 56225-81-1 N,N-dimethyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)-1-propylamine 

Relevant articles and documents

Derivatization of common antidepressant drugs increases inhibition of acid sphingomyelinase and reduces induction of phospholipidosis

In recent studies, major depressive disorder (MDD) was linked to an increase in acid sphingomyelinase (ASM) activity. Several drugs that are commonly used to treat MDD functionally inhibit the lysosomal enzyme ASM and are called functional inhibitors of ASM (FIASMAs). These drugs are classified as cationic amphiphilic drugs (CADs) that influence the catalytic activities of different lysosomal enzymes. This action results in the side effect of phospholipidosis (PLD), which describes a detrimental increase in the phospholipid content in lysosomes. FIASMAs differ only slightly in their physico-chemical properties, but their effects on ASM activity and induction of the lysosomal phospholipid content vary significantly. In this study, we systematically induced minor chemical modifications to the FIASMAs imipramine, desipramine and fluoxetine. We generated a library of 45 new CADs with slightly different log P (logarithmic partition coefficient) and pKa (logarithmic acid dissociation constant) values. The effects of the compounds on the ASM activity and lysosomal phospholipid content were assessed in cell culture assays. We identified four compounds with beneficial effects, i.e., increased ASM activity inhibition and reduced PLD induction compared with the original drugs. The compounds HT04, RH272B and RH272D outperformed the original imipramine, whereas RH281A performed better than desipramine. Thus, minor chemical variations of CADs impact lysosomal metabolism in a specific manner and can lead to antidepressant drugs with less deleterious side effects.

STUDIES ON PHENYLALKANETHIOLAMINE. I. SYNTHESES OF 1-PHENYL-2(OR

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