79230-00-5

Basic information

• Product Name: (Z)-methyl 3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)acrylate
• Synonyms: (Z)-methyl 3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)acrylate
• CAS NO: 79230-00-5
• Molecular Weight: 313.353
• Mol File: 79230-00-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-methyl 3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-methyl 3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)acrylate(79230-00-5)
• EPA Substance Registry System: (Z)-methyl 3-(4-methoxyphenyl)-3-(4-methoxyphenylamino)acrylate(79230-00-5)

Safety Data

• Hazardous Substances Data: 79230-00-5(Hazardous Substances Data)

Upstream product

• 22027-50-5 methyl 3-(4-methoxybenzoyl)acetate 
• 104-94-9 4-methoxy-aniline 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 5720-07-0 4-methoxyphenylboronic acid 
• 7515-17-5 methyl 3-(4-methoxyphenyl)propynoate 

Relevant articles and documents

Copper(ii)-catalyzed synthesis of multisubstituted indoles through sequential Chan-Lam and cross-dehydrogenative coupling reactions

Starting from arylboronic acids and ester (Z)-3-aminoacrylates, one-pot syntheses of diverse indole-3-carboxylic esters have been described through copper(ii)-catalyzed sequential Chan-Lam N-arylation and cross-dehydrogenative coupling (CDC) reactions. The initial Chan-Lam arylation can proceed in DMF at 100 °C for 24 h to give ester (Z)-3-(arylamino)acrylate intermediates in the presence of Cu(OAc)2/tri-tert-butylphosphine tetrafluoroborate, a catalytic amount of myristic acid as the additive, KMnO4 and KHCO3. Sequentially, these in situ arylated intermediates can undergo an intramolecular oxidative cross-dehydrogenative coupling process in mixed solvents (DMF/DMSO = 2 : 1) at 130 °C to give C3-functionalized multi-substituted indole derivatives. This journal is

REACTIONS OF METHYL 3-ARYL-2-PROPYONATES WITH NUCLEOPHILIC NITROGEN COMPOUNDS

Benzylamine reacts with methyl 3-phenyl-(IVa) and methyl 3-(p-methoxyphenyl)-(IVb)2-propynoates to give the corresponding N-benzyl-3-aryl-2-propynoic amides (Va and b).On the other hand, methyl 3-(p-chlorophenyl)-2-propynoate (IVc) give methyl (Z)-β-benzylamino-p-chlorocinnamate (VIa). p-Methylaminobenzene and p-methoxyaminobenzene react with IVa-c to give the corresponding methyl (Z)-β-(arylamino)cinnamates (VIb-g).Similarly, o-phenylenediamine gave with IVc, methyl (Z)-β-(o-aminoanilino)-p-chlorocinnamate (VII).Benzoylhydrazine reacts with IVa and b to give the corresponding 1H-3-aryl-1-benzoyl-5-hydroxypyrazole (VIIIa and b); VIIIa was converted into the known 3-phenylpyrazol-5-one by the action of concentrated hydrochloric acid.Benzamidine hydrochloride and IVa-c in the presence of aqueous sodium carbonate give the correesponding methyl (Z)-β-benzamidinocinnamates (IXa-c).