79230-02-7

Basic information

• Product Name: (Z)-3-(4-Methoxy-phenyl)-3-p-tolylamino-acrylic acid methyl ester
• CAS NO: 79230-02-7
• Molecular Weight: 297.354
• Mol File: 79230-02-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (Z)-3-(4-Methoxy-phenyl)-3-p-tolylamino-acrylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-(4-Methoxy-phenyl)-3-p-tolylamino-acrylic acid methyl ester(79230-02-7)
• EPA Substance Registry System: (Z)-3-(4-Methoxy-phenyl)-3-p-tolylamino-acrylic acid methyl ester(79230-02-7)

Safety Data

• Hazardous Substances Data: 79230-02-7(Hazardous Substances Data)

Upstream product

• 7515-17-5 methyl 3-(4-methoxyphenyl)propynoate 
• 106-49-0 p-toluidine 
• 5720-05-8 4-methylphenylboronic acid 

Relevant articles and documents

Copper(ii)-catalyzed synthesis of multisubstituted indoles through sequential Chan-Lam and cross-dehydrogenative coupling reactions

Starting from arylboronic acids and ester (Z)-3-aminoacrylates, one-pot syntheses of diverse indole-3-carboxylic esters have been described through copper(ii)-catalyzed sequential Chan-Lam N-arylation and cross-dehydrogenative coupling (CDC) reactions. The initial Chan-Lam arylation can proceed in DMF at 100 °C for 24 h to give ester (Z)-3-(arylamino)acrylate intermediates in the presence of Cu(OAc)2/tri-tert-butylphosphine tetrafluoroborate, a catalytic amount of myristic acid as the additive, KMnO4 and KHCO3. Sequentially, these in situ arylated intermediates can undergo an intramolecular oxidative cross-dehydrogenative coupling process in mixed solvents (DMF/DMSO = 2 : 1) at 130 °C to give C3-functionalized multi-substituted indole derivatives. This journal is