792911-91-2

Basic information

• Product Name: methyl 2-chloro-5-((trimethylsilyl)ethynyl)benzoate
• Synonyms: methyl 2-chloro-5-((trimethylsilyl)ethynyl)benzoate
• CAS NO: 792911-91-2
• Molecular Weight: 266.799
• Mol File: 792911-91-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl 2-chloro-5-((trimethylsilyl)ethynyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-chloro-5-((trimethylsilyl)ethynyl)benzoate(792911-91-2)
• EPA Substance Registry System: methyl 2-chloro-5-((trimethylsilyl)ethynyl)benzoate(792911-91-2)

Safety Data

• Hazardous Substances Data: 792911-91-2(Hazardous Substances Data)

Upstream product

• 19094-56-5 2-chloro-5-iodobenzoic acid 
• 251085-87-7 methyl 5-bromo-2-chloro-benzoate 
• 1066-54-2 trimethylsilylacetylene 
• 21739-92-4 5-bromo-2-chlorobenzoic acid 
• 620621-48-9 3-carboxymethyl-4-chloro-1-iodobenzene 

Downstream Products

• 792911-92-3 methyl 5-acetyl-2-chlorobenzoate 
• 1031418-85-5 C₁₃H₁₄ClNO₃ 
• 1333869-56-9 C₁₄H₁₆ClNO₃ 
• 792911-68-3 2-chloro-N-(1-hydroxy-cycloheptylmethyl)-5-(5-methyl-1H-pyrazol-3-yl)-benzamide 
• 792911-93-4 2-chloro-5-(5-methyl-1H-pyrazol-3-yl)-benzoic acid methyl ester 
• 1031418-02-6 2-chloro-5-(1H-pyrazol-3-yl)benzoic acid 
• 1143023-55-5 2-chloro-5-ethyl-N-(6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)benzamide 
• 1143020-09-0 2-chloro-5-ethynylbenzamide 
• 1143023-36-2 2-chloro-5-ethynyl-N-[[6-[3-(4-methylpiperazin-1-yl)propylsulfonyl]benzothiazol-2-yl]carbamoyl]benzamide 
• 1416900-12-3 C₂₂H₁₄Cl₃F₇N₄OS 
• 1416899-92-7 2-chloro-N-cyclopropyl-5-{1-[2,6-dichloro-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)phenyl]-1H-[1,2,3]triazol-4-yl}benzamide 
• 1416900-80-5 2-chloro-5-{1-[2,6-dichloro-4-(1,2,2,2-tetrafluoro-1-trifluoromethyl-ethyl)-phenyl]-1H-[1,2,3]triazol-4-yl}-benzoic acid 
• 1416900-81-6 methyl 2-chloro-5-{1-[2,6-dichloro-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenyl]1H-1,2,3-triazol-4-yl}benzoate 
• 792912-10-8 2-chloro-5-ethynyl-benzoic acid methyl ester 

Relevant articles and documents

Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists

Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by lowering the set-point for hunger between meals. We identified an acylurea series of ghrelin modulators from high throughput screening and optimized binding affinity through structure-activity relationship studies. Furthermore, we identified specific substructural changes, which switched partial agonist activity to inverse agonist activity, and optimized physicochemical and DMPK properties to afford the non-CNS penetrant inverse agonist 22 (AZ-GHS-22) and the CNS penetrant inverse agonist 38 (AZ-GHS-38). Free feeding efficacy experiments showed that CNS exposure was necessary to obtain reduced food intake in mice, and it was demonstrated using GHS-R1a null and wild-type mice that this effect operates through a mechanism involving GHS-R1a.

Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X7 receptor

The discovery, of a series of 2-Cl-5-heteroaryl-benzamide antagonists of the P2X7 receptor via parallel medicinal chemistry is described. Initial analogs suffered from poor metabolic stability and low Vdss. Multi parametric optimizat

BENZAMIDE INHIBITORS OF THE P2X7 RECEPTOR

The present invention provides benzamide inhibitors of the P2X7 receptor of the formula (I), wherein R1 -R3 are as defined herein. The compounds of the invention are useful in the treatment of IL-1 mediated disorders, incl