79307-55-4Relevant articles and documents
Copper-catalyzed synthesis of thiazol-2-yl ethers from oxime acetates and xanthates under redox-neutral conditions
Zhu, Zhongzhi,Tang, Xiaodong,Cen, Jinghe,Li, Jianxiao,Wu, Wanqing,Jiang, Huanfeng
, p. 3767 - 3770 (2018/04/17)
A novel copper-catalyzed annulation of oxime acetates and xanthates for the synthesis of thiazol-2-yl ethers with remarkable regioselectivity has been developed. Various oxime acetates, whether derived from aryl ketones or alkyl ketones, or natural product cores are suitable for this conversion. Unique dihydrothiazoles were also obtained when both reaction sites were methine. Mechanistic studies indicated that imino copper(iii) intermediates were involved. In addition, this protocol proceeded under redox-neutral conditions and did not require additives or ligands.
The Structures of 4- and 5-Substituted Δ4-Thiazolin-2-ones
Cornwell, Stephen P.,Kaye, Perry T.,Kent, Alexander G.,Meakins, G. Denis
, p. 2340 - 2343 (2007/10/02)
In order to establish the structures of compounds described as Δ4-thiazolin-2-ones ten sets of heterocycles (each comprising a 4- or 5-substituted Δ4-thiazolin-2-one, the N-methyl derivative, and the corresponding 2-methoxythiazole) have been examined by i.r., u.v., and 1H and 13C n.m.r. spectrometry.The i.r. results established that in solution the parent compounds exist entirely or predominantly as the 2-oxo-forms.This conclusion is supported by the 1H n.m.r. evidence, but the u.v. and 13C n.m.r. data do not give a clear distinction between the possible 2-oxo- and 2-hydroxy-structures.
