79341-69-8Relevant articles and documents
The occurrence of phenylpyruvic acid in woody plants: Biosynthetic significance
Marais, Charlene,Steenkamp, Jacobus A.,Ferreira, Daneel
, p. 5763 - 5764 (1996)
The leaves and stems of Aspalathus linearis, a member of the Fabaceae, contains (Z)-3-phenyl-2-β-D-glucopyranosyloxypropenoic acid, an enolic glucoside of phenylpyruvic acid which is of relevance to the shikimic acid pathway.
New 3- and 4-hydroxyfuranones as anti-oxidants and anti-inflammatory agents
Weber, Valerie,Rubat, Catherine,Duroux, Eliane,Lartigue, Claire,Madesclaire, Michel,Coudert, Pascal
, p. 4552 - 4564 (2007/10/03)
Two series of new furanones substituted by methylsulfonylphenyl or methylsulfamidophenyl moieties were found to protect against oxidation damage by inhibiting or quenching free radicals and reactive oxygen species in in vitro experiments. The effect on lipid peroxidation was also examined. In addition, we investigated the activity of products in two models of inflammation: phorbol ester-induced ear edema in mice and carrageenan-induced paw edema in rat. The most powerful compounds and with reducing activity against DPPH (IC50 = 1779 and 57 μM, respectively), superoxide anion quenching capacity (IC50 = 511 and 49 μM, respectively), lipid peroxidation inhibitory effect and anti-inflammatory properties (about 50-65% inhibition of edema at 200 mg/kg ip in both tests used) were selected for further pharmacological and toxicological tests because of their attractive profile for the treatment of inflammatory diseases.
