79364-48-0Relevant articles and documents
THE SYNTHESIS OF 3-(ALDITOL-1-YL)-1,2,4-TRIAZOLOPHTHALAZINES
Shaban, Mohammed A. E.,Ali, Raafat S.,El-Badry, Sousan M.
, p. 51 - 60 (1981)
Condensation of 1-hydrazinophthalazine (hydralazine) with D-lyxose, D-ribose, D-xylose, D-mannose, and L-rhamnose gave the corresponding aldehydo-sugar phthalazin-1-ylhydrazones.D-arabinose and d-galactose, on the other hand, gave the corresponding 3-(alditol-1-yl)-1,2,4-triazolophthalazines through the autodehydrogenative cyclization of the hydrazones.A rationale for this difference is discussed.Acetylation of the latter gave the poly-O-acetyl derivatives.Catalytic, dehydrogenative cyclization with palladium-on-charcoal, or acetylation, transforms the hydrazones into the triazolophthalazines, or their acetates.The mass spectra of the synthesized compounds were discussed.