79421-38-8

Basic information

• Product Name: Benzoic acid, 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-, ethyl ester
• Synonyms: Benzoic acid, 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-, ethyl ester;ETHYL 4-(1,4-DIOXA-8-AZASPIRO[4.5]DECAN-8-YL)BENZOATE
• CAS NO: 79421-38-8
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.34224
• Mol File: 79421-38-8.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Benzoic acid, 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-, ethyl ester(79421-38-8)
• EPA Substance Registry System: Benzoic acid, 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-, ethyl ester(79421-38-8)

Safety Data

• Hazardous Substances Data: 79421-38-8(Hazardous Substances Data)

Usage

Description

Benzoic acid, 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-, ethyl ester is a chemical compound that belongs to the group of esters. It is composed of benzoic acid and ethyl ester, and also contains a 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl) group. It is known for its aromatic and fruity odor, making it a versatile and valuable chemical compound in various fields including food science, pharmaceuticals, and cosmetics.

Uses

Used in Food and Beverage Industry:
Benzoic acid, 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-, ethyl ester is used as a flavoring agent for its aromatic and fruity odor, enhancing the taste and aroma of various food and beverage products.
Used in Pharmaceutical Industry:
Benzoic acid, 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-, ethyl ester is used in pharmaceuticals due to its potential antifungal and antimicrobial properties, making it a valuable compound in the development of medications and treatments.
Used in Cosmetic Industry:
Benzoic acid, 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-, ethyl ester is used in cosmetics for its aromatic properties, contributing to the scent and overall sensory experience of cosmetic products.

Upstream product

• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 177-11-7 4,4-ethylenedioxy-piperidine 
• 42923-77-3 6-methoxy-1,2,3,4-tetrahydro-isoquinoline 
• 584-08-7 potassium carbonate 

Downstream Products

• 25437-95-0 4-(4-Oxo-1-piperidinyl)benzoic acid ethyl ester 
• 340756-74-3 4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)benzoic acid 
• 197446-34-7 4-(4-oxo-piperidin-1-yl)-benzoic acid 
• 340756-90-3 ethyl {[4-(4-oxo-1-piperidinyl)benzoyl]amino}acetate 
• 340756-92-5 methyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-prolinate 
• 340756-93-6 ethyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-valinate 
• 340756-94-7 ethyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-leucinate 
• 340809-44-1 methyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-phenylalaninate 
• 340756-91-4 3-[4-(4-oxopiperidin-1-yl)benzoylamino]propionic acid benzyl ester 
• 340756-95-8 dibenzyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-glutamate 
• 340756-96-9 ethyl [(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)amino]acetate 
• 340756-97-0 methyl 1-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-prolinate 
• 340756-98-1 ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-valinate 
• 340756-99-2 ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate 

Relevant articles and documents

Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF

Peptidoglycan is an essential component of the bacterial cell wall, and enzymes involved in its biosynthesis represent validated targets for antibacterial drug discovery. MurF catalyzes the final intracellular peptidoglycan biosynthesis step: the addition of D-Ala-D-Ala to the nucleotide precursor UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP (or L-Lys). As MurF has no human counterpart, it represents an attractive target for the development of new antibacterial drugs. Using recently published cyanothiophene inhibitors of MurF from Streptococcus pneumoniae as a starting point, we designed and synthesized a series of structurally related derivatives and investigated their inhibition of MurF enzymes from different bacterial species. Systematic structural modifications of the parent compounds resulted in a series of nanomolar inhibitors of MurF from S. pneumoniae and micromolar inhibitors of MurF from Escherichia coli and Staphylococcus aureus. Some of the inhibitors also show antibacterial activity against S. pneumoniae R6. These findings, together with two new co-crystal structures, represent an excellent starting point for further optimization toward effective novel antibacterials.

APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE

Compounds of formula (I), and salts, N-oxides, hydrates and solvates thereof are histone deacetylase inhibitors and are useful in the treatment of cell proliferative diseases, including cancers: wherein Q, V and W independently represent -N= or -C=; B is