79435-04-4Relevant articles and documents
Synthesis of diaryl acetates and oxindoles via a sequential VNS Ar-SNAr three-component coupling reaction
Lawrence, Nicholas J.,Davies, Christopher A.,Gray, Matthew
, p. 4957 - 4960 (2007/10/03)
(Chemical Equation Presented) The VNS and SNAr reactions combine to form an efficient three-component one-pot route to diarylmethanes. The products of selected diaryl acetates provide modular 3-aryloxindole derivatives.
Process for the preparation of an alkyl 2-chloropropionate by chlorinating an alkyl lactate
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, (2008/06/13)
A racemic or optically active alkyl 2-chloropropionate is prepared, respectively, from a racemic or optically active alkyl lactate by, in a first step, gradually bringing the alkyl lactate into contact with the thionyl chloride, in the presence of an organic base, while maintaining, in the reaction mixture, an excess of thionyl chloride, relative to the amount of alkyl lactate introduced into this mixture, at a temperature below the decomposition point of the chlorosulphinate of the alkyl lactate, which is formed as an intermediate, and then, in a second step, in heating the reaction mixture resulting from the first step at a temperature which is at least equal to the decomposition point of the chlorosulphinate of the alkyl lactate. The alkyl 2-chloropropionates can be used for the manufacture of the racemic or optically active 2-phenoxypropionic acids.
