79442-34-5

Basic information

• Product Name: 2-Propen-1-one, 3-(4-methylphenyl)-1-(2-thienyl)-, (E)-
• CAS NO: 79442-34-5
• Molecular Formula: C14H12OS
• Molecular Weight: 228.315
• Mol File: 79442-34-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 3-(4-methylphenyl)-1-(2-thienyl)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 3-(4-methylphenyl)-1-(2-thienyl)-, (E)-(79442-34-5)
• EPA Substance Registry System: 2-Propen-1-one, 3-(4-methylphenyl)-1-(2-thienyl)-, (E)-(79442-34-5)

Safety Data

• Hazardous Substances Data: 79442-34-5(Hazardous Substances Data)

Upstream product

• 4075-59-6 2-thiopheneglyoxylic acid 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 88-15-3 2-Acetylthiophene 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 128342-36-9 6-(thiophen-2-yl)-2-thioxo-4-(p-tolyl)-1,2-dihydro-pyridine-3-carbonitrile 
• 214618-42-5 1-(thiophen-2-yl)-3-(p-tolyl)propan-1-one 
• 1641554-31-5 4-(4-methylphenyl)-2-(thiophen-2-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepine 
• 1595291-82-9 3-(4-methylphenyl-3-oxo-1-(2-thienyl)propyl)propanedinitrile 
• 1595291-96-5 4-(4-methylphenyl)-2-[1-(4-methylpiperazinyl)]-6-(2-thienyl)-3-pyridinecarbonitrile 
• 1595291-90-9 4-(4-methylphenyl)-2-(4-morpholinyl)-6-(2-thienyl)-3-pyridinecarbonitrile 
• 1595291-86-3 4-(4-methylphenyl)-2-(1-piperidinyl)-6-(2-thienyl)-3-pyridinecarbonitrile 
• 1595291-83-0 2-bromo-4-(4-methylphenyl)-6-(2-thienyl)-3-pyridinecarbonitrile 
• 1586789-88-9 diethyl 2-(3-oxo-3-(thiophen-2-yl)-1-p-tolylpropyl)malonate 
• 1586790-08-0 6-(thiophen-2-yl)-4-p-tolyl-3,4-dihydropyridin-2(1H)-one 
• 1333228-64-0 C₁₅H₁₂N₂S₂ 
• 1333228-59-3 C₁₅H₁₂N₂OS 

Relevant articles and documents

Studies of NMR Chemical Shifts of Chalcone Derivatives of Five-membered Monoheterocycles and Determination of Aromaticity Indices

A series of the chalcone derivatives of the five-membered monoheterocyclic compounds, (E)-1-aryl-3-heteroarylpropen-1-ones, were prepared by aldol condensation of the corresponding aldehydes of thiophene, pyrrole, and furan with m- and p-substituted acetophenones. Similar condensation of the acetyl compounds of the heterocycles with m- and p-substituted benzaldehydes gave another series of the chalcone derivatives, (E)-1-heteroaryl-3-arylpropen-1-ones. The 13C chemical shift values (δC) of the chalcone derivatives were determined in order to find if they correlated with the Hammett σ values. A good correlation, especially for the β-C for both series, was found for the 13C chemical shift values (δC) of the chalcone derivatives with the Hammett σ values. The chemical shift values of the β-C of the heterocyclic compounds were plotted against those of the benzene derivatives. The resulting slopes were found to be close to the values of the aromaticity indices.

Domino-Fluorination-Protodefluorination Enables Decarboxylative Cross-Coupling of α-Oxocarboxylic Acids with Styrene via Photoredox Catalysis

Domino-fluorination-protodefluorination decarboxylative cross-coupling of α-keto acids with styrene has been developed via photoredox catalysis. The critical part of this strategy is the formation of the carbon-fluorine (C-F) bond by the capture of a carbon-centered radical intermediate, which will overcome side reactions during the styrene radical functionalization process. Experimental studies have provided evidence indicating a domino-fluorination-protodefluorination pathway with α-keto acid initiating the photoredox cycle. The present catalytic protocol also affords a novel approach for the construction of α,β-unsaturated ketones under mild conditions.

Design and synthesis of spiro derivatives containing a thiophene ring and evaluation of their anti-microbial activity

Synthesis of a series of novel spiro pyrrolidines has been accomplished by 1, 3-dipolar cycloaddition reaction of azomethine ylide generated from phenylalanine and isatin with dipolarophiles in good yield. The reaction proceeded with high regio and stereoselectivity. The products have been characterized by elemental analyses and spectroscopic techniques, namely IR, 1H NMR and 13C NMR spectroscopies. Single crystal analysis of compounds 4k 2D-NMR analysis of compound 4k confirmed the structures of spiropyrrolidine derivatives. These compounds were evaluated for their antimicrobial activity. Most of the synthetic compounds exhibited good activity against microorganisms.