794524-05-3Relevant articles and documents
High-throughput assay for quantification of aminoglycoside-Ribosome interaction
Yamashita, Shun,Bergmann, Dominik,Sato, Ayato,Nomoto, Mika,Tada, Yasuomi,Humpf, Hans-Ulrich,Itami, Kenichiro,Hagihara, Shinya
, p. 1048 - 1050 (2016)
The serious side effects of aminoglycosides and the spread of aminoglycoside-resistant strains have restricted the clinical application of aminoglycosides. A compound with the identical mode of action with aminoglycosides and with different molecular skeleton would be an alternative drug for aminoglycosides. In this study, we constructed an SPR-based high-throughput screening system for the discovery of such compounds.
Di-alkylated paromomycin derivatives: Targeting the membranes of Gram positive pathogens that cause skin infections
Berkov-Zrihen, Yifat,Herzog, Ido M.,Feldman, Mark,Sonn-Segev, Adar,Roichman, Yael,Fridman, Micha
, p. 3624 - 3631 (2013/07/11)
A collection of paromomycin-based di-alkylated cationic amphiphiles differing in the lengths of their aliphatic chain residues were designed, synthesized, and evaluated against 14 Gram positive pathogens that are known to cause skin infections. Paromomyci