79492-49-2

Basic information

• Product Name: 2-amino-3-cyano-4-phenyl-6-(4'-hydroxyphenyl)-pyridine
• Synonyms: 2-amino-3-cyano-4-phenyl-6-(4'-hydroxyphenyl)-pyridine
• CAS NO: 79492-49-2
• Molecular Weight: 287.321
• Mol File: 79492-49-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2-amino-3-cyano-4-phenyl-6-(4'-hydroxyphenyl)-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-3-cyano-4-phenyl-6-(4'-hydroxyphenyl)-pyridine(79492-49-2)
• EPA Substance Registry System: 2-amino-3-cyano-4-phenyl-6-(4'-hydroxyphenyl)-pyridine(79492-49-2)

Safety Data

• Hazardous Substances Data: 79492-49-2(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 109-77-3 malononitrile 
• 99-93-4 4-Hydroxyacetophenone 
• 2657-25-2 4'-hydroxychalcone 
• 2700-22-3 Benzylidenemalononitrile 

Relevant articles and documents

β-Cyclodextrin: A supramolecular catalyst for metal-free approach towards the synthesis of 2-amino-4,6-diphenylnicotinonitriles and 2,3-dihydroquinazolin-4(1 H)-one

β-Cyclodextrin, a green and widespread supramolecular catalyst, has been explored as a highly proficient promoter for the metal-free one-pot multi-component synthesis of a vast range of highly functionalized bioactive heterocyclic moiety, 2-amino-4,6-diphenylnicotinonitriles and 2,3-dihydroquinazolin-4(1H)-one, from easily available precursor aldehydes. The main endeavor of these protocols is to explore this organic supramolecule in one-pot multi-component synthesis. Absence of metal catalyst or toxic acid and harsh reaction conditions, excellent functional group tolerance, inexpensive, greener and environmentally safe protocol are the key advantages of this work.

Synthesis of a novel acidic ionic liquid catalyst and its application for preparation of pyridines via a cooperative vinylogous anomeric-based oxidation

Abstract: In the current study, a novel acidic ionic liquid catalyst based on 8-hydroxyquinoline, namely 8,8′,8″-([1,3,5-triazine-2,4,6-triyl]tris[oxy])tris(1-sulfoquinolin-1-ium)chloride (TTS), was designed and synthesized. The structure of the prepared acidic ionic liquid (AIL) was fully investigated by using Fourier transform infrared (FT-IR) spectroscopy, energy dispersive X-ray (EDX) analysis, thermogravimetric analysis/differential thermal analysis (TGA/DTA), 1HNMR, 13CNMR and mass spectroscopy. Then, the catalytic performance of described AIL was successfully inspected toward the four-component synthesis of pyridine derivatives via a cooperative vinylogous anomeric-based oxidation. Graphic abstract: Novel AIL (TTS) showed a very high efficiency in the synthesis of pyridines. [Figure not available: see fulltext.].

Experimental and theoretical studies of the nanostructured {Fe3O4@SiO2@(CH2)3Im}C(CN)3 catalyst for 2-amino-3-cyanopyridine preparation: Via an anomeric based oxidation

2-Amino-4,6-diphenylnicotinonitriles were prepared by using Fe3O4@SiO2@(CH2)3Im}C(CN)3 as a nanostructured catalyst with an ionic liquid tag under solvent free and benign conditions. Experimental evidence and theoretical studies confirmed that the final step of the synthetic pathway proceeded via an anomeric based oxidation mechanism. A good range of aromatic aldehydes were condensed with acetophenone derivatives, malononitrile and ammonium acetate to afford their corresponding products in short reaction times and good to high yields.