795275-74-0Relevant articles and documents
Re-evaluating the nucleophilicity of zinc enolates in alkylation reactions
Jarugumilli, Gopala K.,Zhu, Chunyin,Cook, Silas P.
, p. 1712 - 1715 (2012)
The use of toluene allows for allylic and benzylic alkylation of zinc enolates, derived from an asymmetric copper-catalyzed conjugate addition of dialkylzinc, using a range of valuable electrophiles. The one-pot procedure avoids the use of additional transition-metal catalysts and does not require highly activated electrophiles.
A simple, nontoxic iron system for the allylation of zinc enolates
Jarugumilli, Gopala K.,Cook, Silas P.
scheme or table, p. 1904 - 1907 (2011/06/22)
Diiron nonacarbonyl in combinationwith triphenylphosphine has been identified as a low-cost and environmentally benign catalyst system for the allylation of zinc enolates generated in situ from copper-catalyzed asymmetric conjugate addition reactions. The
The asymmetric synthesis of (-)-pumiliotoxin C using tandem catalysis
Dijk, Ewold W.,Panella, Lavinia,Pinho, Pedro,Naasz, Robert,Meetsma, Auke,Minnaard, Adriaan J.,Feringa, Ben L.
, p. 9687 - 9693 (2007/10/03)
The potent neurotoxin (-)-pumiliotoxin C has been prepared in 8 steps starting from 2-cyclohexenone. Key steps are a tandem asymmetric conjugate addition-allylic substitution reaction and a tandem Heck-allylic substitution reaction. Graphical Abstract.
