79536-95-1

Basic information

• Product Name: N²-isobutyryl-2'-O-(tert-butyldimethylsilyl)-5'-O-(monomethoxytrityl)guanosine
• CAS NO: 79536-95-1
• Molecular Weight: 739.944
• Mol File: 79536-95-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N²-isobutyryl-2'-O-(tert-butyldimethylsilyl)-5'-O-(monomethoxytrityl)guanosine(CAS DataBase Reference)
• NIST Chemistry Reference: N²-isobutyryl-2'-O-(tert-butyldimethylsilyl)-5'-O-(monomethoxytrityl)guanosine(79536-95-1)
• EPA Substance Registry System: N²-isobutyryl-2'-O-(tert-butyldimethylsilyl)-5'-O-(monomethoxytrityl)guanosine(79536-95-1)

Safety Data

• Hazardous Substances Data: 79536-95-1(Hazardous Substances Data)

Upstream product

• 118-00-3 G 
• 67607-83-4 N²-Isobutyroyl-5'-O-(4-methoxytrityl)guanosin 
• 70337-80-3 N²-(2-methylpropanoyl)-2',3',5'-tris-O-(2-methylpropanoyl)guanosine 
• 64350-24-9 N²-isobutyryl-2'-deoxyguanosine 
• 79983-16-7 N²-isobutyryl-3'-O-(tert-butyldimethylsilyl)-5'-O-(monomethoxytrityl)guanosine 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 112343-21-2 C₆₁H₇₇ClN₇O₁₅PSi₂ 
• 112343-25-6 C₆₉H₈₂ClN₁₀O₁₄PSi₂ 

Relevant articles and documents

Nucleosides, XXXVII. - Synthesis and Properties of 2'-O- and 3'-O-(tert-Butyldimethylsilyl)-5'-O-(4-methoxytrityl)- and 2',3'-Bis(O-tert-butyldimethylsilyl)ribonucleosides - Starting Materials for Oligoribonucleotide Syntheses

The synthesis of aminoacylated 5'-O-(4-methoxytrityl)ribonucleosides of adenosine (1), guanosine (9), cytidine (31), uridine (17), and 5,6-dihydrouridine (23) have been optimized and these compounds (4, 12, 33, 18 and 24) silylated by tert-butyldimethylsilyl chloride.The corresponding 2'- and 3'-mono-O- as well as 2',3'-bis-O-(tert-butyldimethylsilyl) derivatives have been isolated by combination of chromatographical methods and fractional crystallization procedures in preparative scale.The characterization of the newly synthesized compounds was achieved by UV and 13C-NMR spectra.