796090-28-3

Basic information

• Product Name: 5-chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid
• CAS NO: 796090-28-3
• Molecular Weight: 225.555
• Mol File: 796090-28-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid(796090-28-3)
• EPA Substance Registry System: 5-chloro-4-(trifluoromethyl)pyridine-3-carboxylic acid(796090-28-3)

Safety Data

• Hazardous Substances Data: 796090-28-3(Hazardous Substances Data)

Upstream product

• 796090-26-1 3-chloro-4-(trifluoromethyl)-2-(trimethylsilyl)pyridine 
• 81565-19-7 4-(trifluoromethyl)nicotinyl chloride 
• 77332-79-7 3-chloro-4-iodopyridine 
• 1026008-61-6 5-chloro-4-trifluoromethyl-6-trimethylsilanyl-nicotinic acid 

Relevant articles and documents

Three chloro(trifluoromethyl)pyridines as model substrates for regioexhaustive functionalization

As a further test of the concept of regioexhaustive functionalization, 2-chloro-6-(trifluoromethyl)pyridine, 2-chloro-5-(trifluoromethyl)pyridine and 3-chloro-4-(trifluoromethyl)-pyridine were each converted into the three possible carboxylic acids 2, 4, 6, 8, 10, 12, 16, 17 and 20. This was achieved by employing several, but not all of the organometallic "tool-box methods": transformation of a more basic organometallic species into a less basic isomer by transmetalation-equilibration, site discriminating deprotonation with lithium N,N-diisopropylamide or lithium 2,2,6,6- tetramethylpiperidide, regio-divergent iodine migration and steric screening of acidic positions by a bulky trialkylsilyl group. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.