79635-54-4Relevant articles and documents
Syntheses and studies of multiwarhead siderophore-5-fluorouridine conjugates
Lu, Yong,Miller, Marvin J.
, p. 3025 - 3038 (1999)
Siderophores are microbial iron chelating agents that sequester physiologically essential iron for microbes. Conjugation of drugs to siderophores allows use of active iron transport for microbially directed drug delivery. Syntheses and biological studies are described of the first multidrug isocyanurate-based siderophore analogues separately containing one, two, and three 5-fluorouridine (5-FU) derivatives as the drug component. The results indicate that a single siderophore can be used to deliver multiple drugs to target pathogenic microorganisms. Copyright (C) 1999 Elsevier Science Ltd.
Nucleoside derivatives and process for preparing same
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, (2008/06/13)
New nucleoside derivatives possessing strong anti-tumor activity with low toxicity, represented by the general formula: STR1 wherein (A-CO-- is a residue of a saturated straight or branched chain fatty acid, B is a nitrogen-containing group, Q is a substi