79644-38-5

Basic information

• Product Name: Benzene, 1,4-dimethyl-2-(2,2,2-trifluoroethoxy)-
• CAS NO: 79644-38-5
• Molecular Formula: C10H11F3O
• Molecular Weight: 204.192
• Mol File: 79644-38-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 1,4-dimethyl-2-(2,2,2-trifluoroethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,4-dimethyl-2-(2,2,2-trifluoroethoxy)-(79644-38-5)
• EPA Substance Registry System: Benzene, 1,4-dimethyl-2-(2,2,2-trifluoroethoxy)-(79644-38-5)

Safety Data

• Hazardous Substances Data: 79644-38-5(Hazardous Substances Data)

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 420-87-1 sodium 2,2,2-trifluoroethanolate 
• 95-78-3 2,5-Dimethylaniline 
• 93362-61-9 (E)-1,4-Dimethyl-1,3-hexadien-5-in-1-yl-triflat 
• 93362-60-8 (Z)-1,4-Dimethyl-1,3-hexadien-5-in-1-yl-triflat 

Downstream Products

• 1601462-42-3 C₃₆H₄₇F₃O₃Si₂ 
• 1601462-19-4 (E,E)-1-(2,2,2-trifluoroethoxy)-2,5-bis(4-hydroxy)styrylbenzene 
• 1601462-26-3 C₁₈H₂₉F₃O₇P₂ 

Relevant articles and documents

Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands

Detection of cerebral β-amyloid (Aβ) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Aβ imaging agents. To further explore their potency as 19F MRI contrast agents we synthetized several novel fluorinated bis-styrylbenzenes and studied their fluorescent properties and amyloid-β binding characteristics. The compounds showed a high affinity for Aβ plaques on murine and human brain sections. Interestingly, competitive binding experiments demonstrated that they bound to a different binding site than chrysamine G. Despite their high logP values, many bis-styrylbenzenes were able to enter the brain and label murine amyloid in vivo. Unfortunately initial post-mortem 19F NMR studies showed that these compounds as yet do not warrant further MRI studies due to the reduction of the 19F signal in the environment of the brain.

Regiospecific reductive elimination from diaryliodonium salts

(Figure Presented) Out-of-plane steric bulk furnished by a cyclophane substituent on iodine(III) strongly destabilizes the transition state in the reductive elimination from diaryliodonium salts and leads to regiochemical control (dubbed SECURE), as is demonstrated by computational and experimental studies. This approach should be general for high-valent maingroup and transition metal ions. X=N3, OAc, PhO, CF3CH2O, SCN, PhS.

Phenyl Cations as Reactive Intermediates in the Solvolysis of Dien-in-yl Triflates

The synthesis, separation, and solvolysis of the stereoisomeric 1,4-dimethyl-1,3-hexadien-5-yn-1-yl triflates 15a - c in various solvents are described.In contrast to the (Z)-isomers 15a - c, the (E)-isomers 15a - c react preferably via an intermediate phenyl cation 16 to give the phenyl ethers 17.Further mechanistic investigations which support the formation of the intermediate phenyl cations 16 are described.The formation of the benzylic derivatives 18 is discussed.