79672-88-1

Basic information

• Product Name: Piriprost
• Synonyms: Piriprost;(4R)-1,4,5,6-Tetrahydro-5α-hydroxy-4β-[(1E,3S)-3-hydroxy-1-octenyl]-1-phenylcyclopenta[b]pyrrole-2-pentanoic acid;(4R)-1,4,5,6-Tetrahydro-5α-hydroxy-4β-[(E,S)-3-hydroxy-1-octenyl]-1-phenylcyclopenta[b]pyrrole-2-pentanoic acid;U-60257;Cyclopenta(B)pyrrole-2-pentanoic acid, 1,4,5,6-tetrahydro-5-hydroxy-4-((1E,3S)-3-hydroxy-1-octenyl)-1-phenyl-, (4R,5R)-;Cyclopenta(B)pyrrole-2-pentanoic acid, 1,4,5,6-tetrahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-1-phenyl-, (4R-(4alpha(1E,3S*),5beta))-;Piriprostium;Piriprostium [latin]
• CAS NO: 79672-88-1
• Molecular Formula: C26H35NO4
• Molecular Weight: 425.565
• Mol File: 79672-88-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 618.6°C at 760 mmHg
• Flash Point: 327.9°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 3.67E-16mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: Piriprost(CAS DataBase Reference)
• NIST Chemistry Reference: Piriprost(79672-88-1)
• EPA Substance Registry System: Piriprost(79672-88-1)

Safety Data

• Hazardous Substances Data: 79672-88-1(Hazardous Substances Data)

Usage

Uses

Anti-asthmatic.

Enzyme inhibitor

This lipoxygenase-inhibiting pyrrole analogue of prostacyclin (FWpotassium salt = 463.66 g/mol; CAS 79672-88-1), also known as U60257B and 6,9- deepoxy-6,9-(phenylimino)-D6,8-prostaglandin I1, [4R-[4a(1E,3S*),5b]]- 1,4,5,6-tetrahydro-5-hydroxy-4-(3-hydroxy-1-octenyl)-1-phenylcyclopenta[ b]pyrrole-2-pentanoate, inhibits leukotriene C and D formation.1-5 Piriprost also inhibits the release of histamine and leukotrienes from isolated porcine lung cells.6 Note that both priprost and its methyl ester (U-56467) inhibit leukotriene biosynthesis: ID50 = 4.6 and 0.31 μM, respectively. Target(s): glutathione S-transferase; and 5- lipoxygenase, or arachidonate 5-lipoxygenase.

InChI:InChI=1/C26H35NO4/c1-2-3-5-13-21(28)15-16-22-23-17-20(12-8-9-14-26(30)31)27(24(23)18-25(22)29)19-10-6-4-7-11-19/h4,6-7,10-11,15-17,21-22,25,28-29H,2-3,5,8-9,12-14,18H2,1H3,(H,30,31)/b16-15+/t21-,22+,25+/m0/s1