796844-24-1

Basic information

• Product Name: 3-[4-(2,4-BIS-TRIFLUOROMETHYLBENZYLOXY)-3-METHOXYPHENYL]-2-CYANO-N-(5-TRIFLUOROMETHYL-1,3,4-THIADIAZOL-2-YL)ACRYLAMIDE
• Synonyms: XCT790;3-[4-(2,4-BIS-TRIFLUOROMETHYLBENZYLOXY)-3-METHOXYPHENYL]-2-CYANO-N-(5-TRIFLUOROMETHYL-1,3,4-THIADIAZOL-2-YL)ACRYLAMIDE
• CAS NO: 796844-24-1
• Molecular Formula: C23H13F9N4O3S
• Molecular Weight: 596.42
• Mol File: 796844-24-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[4-(2,4-BIS-TRIFLUOROMETHYLBENZYLOXY)-3-METHOXYPHENYL]-2-CYANO-N-(5-TRIFLUOROMETHYL-1,3,4-THIADIAZOL-2-YL)ACRYLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(2,4-BIS-TRIFLUOROMETHYLBENZYLOXY)-3-METHOXYPHENYL]-2-CYANO-N-(5-TRIFLUOROMETHYL-1,3,4-THIADIAZOL-2-YL)ACRYLAMIDE(796844-24-1)
• EPA Substance Registry System: 3-[4-(2,4-BIS-TRIFLUOROMETHYLBENZYLOXY)-3-METHOXYPHENYL]-2-CYANO-N-(5-TRIFLUOROMETHYL-1,3,4-THIADIAZOL-2-YL)ACRYLAMIDE(796844-24-1)

Safety Data

• Hazardous Substances Data: 796844-24-1(Hazardous Substances Data)

Upstream product

• 862179-86-0 2-cyano-N-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)acetamide 
• 796844-14-9 4-((2,4-bis(trifluoromethyl)benzyl)oxy)-3-methoxybenzaldehyde 
• 121-33-5 vanillin 
• 140690-56-8 2,4-bis(trifluoromethyl)benzyl bromide 

Relevant articles and documents

3-PHENYL-N- ((1, 3, 4) THIADIAZOL-2-YL) -ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ESTROGEN-RELATED RECEPTORS FOR THE TREATMENT OF E.G. CANCER, RHEUMATOID ARTHRITIS OR NEUROLOGICAL DISORDERS

Compounds of formula (I) are provided as well as compositions and methods of using compounds of formula (I) for modulating the activity of the estrogen-related receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder related to the activity of the estrogen-related receptor. Considering the wide range of activity of the nuclear hormone receptor ERRα, the compounds described herein which are capable of modulating ERRα activity, are useful for treating a range of disease states including cancer, diabetes, obesity, hyperlipidermia, arthritis, atherosclerosis, osteoporosis, anxiety, depression, Parkinson’s disease and Alzheimer’s disease. Formula (I). The substituents are defined in the claims.