796974-30-6

Basic information

• Product Name: 3-DiMethylaMinoMethylene-4-oxo-pyrrolidine-1-carboxylic acid benzyl ester
• Synonyms: 3-DiMethylaMinoMethylene-4-oxo-pyrrolidine-1-carboxylic acid benzyl ester
• CAS NO: 796974-30-6
• Molecular Formula: C₂₂H₂₂N₂O₄
• Molecular Weight: 274.31502
• EINECS: -0
• Mol File: 796974-30-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 518.4±60.0 °C(Predicted)
• Appearance: /
• Density: 1.303±0.06 g/cm3(Predicted)
• PKA: 3.23±0.40(Predicted)
• CAS DataBase Reference: 3-DiMethylaMinoMethylene-4-oxo-pyrrolidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-DiMethylaMinoMethylene-4-oxo-pyrrolidine-1-carboxylic acid benzyl ester(796974-30-6)
• EPA Substance Registry System: 3-DiMethylaMinoMethylene-4-oxo-pyrrolidine-1-carboxylic acid benzyl ester(796974-30-6)

Safety Data

• Hazardous Substances Data: 796974-30-6(Hazardous Substances Data)

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 158257-34-2 (S)-5-benzyl-1-benzyloxycarbonyl-4-hydroxy-2,5-dihydropyrrol-2-one 
• 1161-13-3 N-Cbz-L-Phe 

Relevant articles and documents

Synthesis of N-substituted 3-ammomethylidenetetramic acids

(S)-3-(Dimethylamino)methylidene-5-benzyltetramic acid derivatives 4a and 4b were prepared in three steps from N-protected (S)-3-phenylalanines 1a and 1b, respectively. Similarly, N-[N-(benzyloxycarbonyl)glycyl]grycine (1c) was transformed into the enamitione 4c. Acid-catalysed coupling of enaminones 4a-c with aliphatic, aromatic, and heteroaromatic primary amines 5-34 afforded the corresponding N(3′)-substituted 3-aminomethylidenetetramic acid derivatives 35-64 in 29-96% yields. Georg Thieme Verlag Stuttgart.