79698-59-2

Basic information

• Product Name: Pyridine, 3-chloro-2,4-bis(trimethylsilyl)- (9CI)
• Synonyms: Pyridine, 3-chloro-2,4-bis(trimethylsilyl)- (9CI)
• CAS NO: 79698-59-2
• Molecular Formula: C11H20ClNSi2
• Molecular Weight: 257.9072
• Product Categories: SILYL
• Mol File: 79698-59-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyridine, 3-chloro-2,4-bis(trimethylsilyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-chloro-2,4-bis(trimethylsilyl)- (9CI)(79698-59-2)
• EPA Substance Registry System: Pyridine, 3-chloro-2,4-bis(trimethylsilyl)- (9CI)(79698-59-2)

Safety Data

• Hazardous Substances Data: 79698-59-2(Hazardous Substances Data)

Upstream product

• 626-60-8 3-Chloropyridine 
• 75-77-4 chloro-trimethyl-silane 

Downstream Products

• 40247-40-3 5,8-endoxo-5,8-dihydroisoquinoline 

Relevant articles and documents

Preparation of Didehydropyridines from (Trimethylsilyl)pyridines

Halogen-substituted (trimethylsilyl)pyridines 2, 3, 5-7 and trifluoromethylsulfonyloxy-substituted (trimethylsilyl)pyridines 9b, 11b are obtained from 2- and 3-halopyridines 1, 4 or hydroxypyridines 8, 10, and 12.Reactions of the 3- and 2-(trimethylsilyl)pyridines 2, 9b and 11b with bases in the presence of furans 15 give only protodesilylation or hydrolysis products but no indication is found for the formation of a 2,3-didehydropyridine. 3-Bromo-4-(trimethylsilyl)pyridine (5a) reacts with KOCMe3 in the presence of furan (15a) to give a mixture of products from which the isoquinoline derivative 20 and the tert-butoxypyridines 23, 24 are formed by addition to 3,4-didehydropyridine.Under comparable conditions far higher yields of 3,4-didehydropyridines are obtained by treatment of the 3-halo-2,4-bis(trimethylsilyl)pyridines 7 with strong bases. Key Words: Didehydropyridines, synthesis of